Tag Archives: multiple sclerosis

Vit D may prevent Multiple sclerosis and reverse the disease indefinitely in mice


Vitamin D based treatments to standard Multiple Sclerosis drugs were compared by a team led by biochemistry researcher Dr. Colleen Hayes, of the University of Wisconsin – Madison.

What did the team discover in mice?

Mice that exhibit MS, were given a single dose of Calcitrol, which is one type of Vit D supplement, followed by dietary Vit D supplements. All the mice got progressively better and regained more neurological function each day. To read the published original article click here.

This work was published in the Journal of Neuroimmunology, August issue of 2013, online.

Hayes believes that the calcitriol may cause the autoimmune cells attacking the nerve cells’ myelin coating to die, while the vitamin D prevents new autoimmune cells from taking their place

(Read more).

Dr Hayes has devoted her career to the study of multiple sclerosis and especially the role of Vitamin D. Current FDA approved MS treatments only work for some MS patients. Her team plans to continue questioning the relevance of Vitamin D in multiple sclerosis diagnosis and treatment.

Clearly, Calcitrol plus Vit D, was more effective than methylprednisonole, has potential for reversing inflammatory demyelinating disease safely and cost effective in mice.  If someone you know is suffering from MS, you might advise them to discuss Dr Hayes’ team’s recent publication with their Physician.  Should they wait until clinical trials are conducted in humans to get exposure to more sunlight and dietary sources of Vit D?

Prior Studies on correlation of Levels of Vit D and MS
Previously some studies have linked low levels of Vitamin D with higher risk of multiple sclerosis (MS).

Inheriting genetic risk factors for multiple sclerosis (MS) is not sufficient to cause this
demyelinating disease of the central nervous system (CNS); exposure to environmental risk factors is also required. MS may be preventable if these unidentified environmental factors can be avoided. MS prevalence increases with decreasing solar radiation, suggesting that sunlight may be protective in MS.

(Read more).

What should we do to prevent Multiple Sclerosis?
The research by Dr Hayes team clearly indicates that a person with multiple sclerosis currently should immediately discuss this published finding on the role of Calcitrol and Vit D in multiple sclerosis therapy.  What if you are related to someone with multiple sclerosis?

Eat more Vit D rich food and supplements
Expose to daily exposure of sunlight
If one day is cloudy, make up for it another sunny day
Winter months with less sunlight exposure must be supplemented with seasonal days with more sunlight exposure

Related Articles:
Worm Theory: to improve the immune system to fight asthma, multiple sclerosis and more

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Can we repair the brain? A UK research-USA industry collaboration


Collaborating transatlantically are UK based Center for Clinical Brain Sciences established as recently as 2004 and USA based Biogen. A landmark clinical study will observe three licensed drugs for neurological conditions. Late stage progressive form of multiple sclerosis (MS) patients will be monitored for two years says Prof. Siddharthan Chandran, Director of the Anne Rowling Clinic. MRI scans will test for signs of MS disease progression. The research initiative is being funded by Biogen. The UK researchers will provide greater insight into the cell and biological processes behind progressive neurological diseases.

Over 35 million people are affected and the global cost for treatment and care is at 700 billion and rising.  Multiple sclerosis progresses fast.  Within 18 months of the first symptoms a person may become wheel chair bound. How does the brain cell wiring system get damaged so rapidly? The hope lies in a new discovery – stem cells can spontaneously repair damaged brain cells, by laying new myelin over nerve cells.  Treatment options being considered for research are by either activating existing stem cells in the brain or by transplanting stem cells to replace dead or dying brain cells. The UK research team has done the ground work for this research since their public is open to the advantages of stem cell research and understand the implications of using a patient’s own stem cells. This risky and super expensive research needs visionary and patient funding leaders. That is where Biogen comes in.  Naturally, such collaborations cannot be done in countries where the citizens do not understand or are opposed to the possibilities of stem cell research.

Dr. Siddharthan Chandran gave a talk at TEDGlobal 2013 describing his vision of hope for neurodegenerative diseases of the brain. See a description of his talk and more images by clicking here or at: http://blog.ted.com/2013/06/12/regenerating-hope-tedglobal-2013-with-siddharthan-chandran/

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Worm Theory: to improve the immune system to fight asthma, multiple sclerosis and more


The probiotic way, where you can introduce worms or germs inside the gut by eating them intentionally, is becoming increasingly mainstream (click here). Have we “poisoned” our guts by making it sterile? Have we “killed” our ability to fight invading microbes like common bacterial infections, or usual allergens like pollen in the spring time? Perhaps, we have made our outside environment too clean, say many physicians today. Maybe, you should eat probiotics.

Worms? Yes, eat small worms or tapeworms for a healthier immune system.

Here is a wonderful article that summarizes the many ways discovered around the world that eating worms can make you healthier. Click here to read this article which also lists several scholarly articles from the year 2000 to 2007 where worms are eaten, worms of all sizes and varieties, fed by physicians in the name of clinical research because physicians are desperate to lessen the suffering of their patients. This site is completely devoted to worm therapy and even has a “frequently asked questions” page; so apparently, people who visited the site had several common questions. Some examples of questions were: “Is it safe?”, “Do I have to go to Mexico?”, “What if I want to get rid of my worms?” and more.

Related Article
Multiple sclerosis and worm therapy: a clinical trial in Argentinia
Autistic child or allergic child and Multiple sclerosis parent
National TV news PBS asks: Why is Autism rising?

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Autistic child or severely Allergic child with Multiple Sclerosis parent


You are not alone if you are in a family with a child diagnosed with an Autistic/ Allergic disorder and an adult diagnosed with Multiple Sclerosis. What has disrupted the lifestyles espoused by the developed world? It is plain to see that our children are far weaker and have severe allergies to food items that our ancestors have eaten for generations and even their grandparents can tolerate well in their old age!

Genetics
The genetic link is suspected to be an autoimmune genes. Yet, inspite of large, genome studies there is no single gene or a group of genes that appear to be common factors. There are several large regions on the chromosomes that share common characteristics among patients with Autism, Aspergers, Multiple Sclerosis, Rheumatoid Arthritis, Crohn’s disease and Autoimmune diseases. The immune genes appear to play a role but no particular set of immune genes stand out. Obviously, genes alone are not responsible for these disorders. 

The dedicated researchers in this field continue to perservere since it is obvious there is a shared set of factors triggering such disorders in a single family. Do contact the researchers and encourage them. These men and women are working long hours to discover these common triggers. Invite them to your support groups and inspire them. Shower them with accolades and let these men and women researchers know that they are our modern “Knights in shining armor”.

Scholarly Publications
Here are three scholarly, peer-reviewed articles discussing their research on the subject:
1) One:
2) Two:
3) Three:

One is by Dr Joseph Piven and colleagues, giving their expert psychiatric analysis of such families and concluding that there is a higher incidence of communication and behavioral deficits in the relatives. Families with Autism were compared with families with Down Syndrome and his conclusion was found only in families with Autism.
His contact information:
Dr. Piven, 1875 John Pappajohn Pavilion, Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242-1057; jpiven@blue.weeg. uiowa.edu (e-mail).

Two is by a team of Psychiatrists and a Pediatrician from Medical Schools in Indiana. Their team studied about 300 families and concluded that autoimmune diseases like rheumatic fever was far more common in parents of children with Autism, Aspergers, ADHD, and such disorders than in parents of children not showing such disorders. They see an immune and autoimmune connection in families with Autistic disorders. They found this finding “unanticipated” and illuminating. In addition, they found this connection was not as strong in patients with PDD NOS and far stronger in patients with Autism and Aspergers. Interesting, right?

They hypothesize a mother to son transmission factor. They conclude this from a particularly important observation that there is a numerical increase in autoimmune diseases in grandmothers and uncles, as well as mothers and brothers of PDD patients. Normally, less men and more women present with autoimmune disorders. Yet, Autism and Aspergers are largely diagnosed in boys.

Contact information:
Thayne L. Sweeten, PhD*, Suzanne L. Bowyer, MD‡, David J. Posey, MD*, Gary M. Halberstadt, DO§, Christopher J. McDougle, MD*
*Departments of Psychiatry
‡Pediatrics, Indiana University School of Medicine, and James Whitcomb Riley Hospital for Children Indianapolis, Indiana
§St Vincent Hospital, Indianapolis, Indiana

Three is by The researchers studied the rates of Autoimmune diseases in parents of 111 infant Autistic patients and naturally, there were more boy patients (82) than girl patients (29). They observed a higher incidence of ulcerative collitis in mothers and Type 1 diabetes in fathers of infant Autism patients in comparison of parents of 330 normal children. The results were published in 2007 in the peer-reviewed journal Developmental Medicine and Child Neurology.

Contact information:
Mouridsen, S. E., Rich, B., Isager, T. and Nedergaard, N. J.
* Correspondence to first author at Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Copenhagen, Denmark. E-mail: sem01@bbh.hosp.dk
1 Department of Child and Adolescent Psychiatry, Bispebjerg University Hospital, Denmark
2 Terrasserne 105, Roskilde, Denmark
3 Center for Child and Adolescent Psychiatry, Glostrup University Hospital, Denmark
4 Psychiatric Hospital for Children and Adolescents, Aarhus University Hospital, Denmark

The scientific authors of these scientific publications on Autism disorders are observing with tempered frustration how uneducated the larger population is of this rising epidemic. They request that you allow for a 30% error in their observations. This error percentage is far higher in experiments allowing for human error. That is because people in general are unaware of the terms and symptoms of this rising epidemic until it hits one dear to them. Your role is to educate the public. Then the researchers in this field will find it easier to get results less prone to “uneducated responses” from their researched families “untouched” by Autoimmune disorders. This societal shift in autoimmune diseases in more boys vs girls and women is what the researchers are following. The numbers of Autistic and Asperger boys are rising each year. They will grow up and outlive their parents, many of whom are suffering from Multiple Sclerosis. Society faces a future it has no previous comprehension of.

Photo credit here.

Related articles:

1) Preparing College Professors for Autistic or Aspergers students
2) Curing Multiple Sclerosis with hook worms
3) Why do Somali children present with Autism in USA and not in Somalia?
4) Why choose a Pecan pie free of corn syrup?
5) Recent advances in Tourettes syndrome treatment

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Multiple Sclerosis cured by hook worms?


In 2007, researchers Dr Correale and Dr Farez, in Argentina discovered that their Multiple Sclerosis patients with a hook worm infection appeared to fare better than those without a worm infection.

Variety of Hookworms

The Intestinal Hookworm

Early clinical trials in MS patients are showing reduction in size of brain lesions. This may not be a cure, but even a low rate of lesion reduction is a promising therapy. What is more important is that this is a natural therapy which shows why people in developing countries may be developing Multiple Sclerosis. There are some clinical trialsunderway, which are trying to see how best to deliver a ‘doze’ of worms or their eggs to get the best results. Brain lesions are being tracked before, during and after a treatment with worms. The initial patterns shown on MRIs is encouraging and studies are in progress.

How does the hook worm act on MS patients? Researchers believe that in MS the immune system has an excessive response to it’s own brain tissue; the presence of the worm’s anti-inflammatory system lessons this response. In doing so, the brain lesions lessen. In other words, the worms suppress the patient’s overactive immune system. The worms need to do this to settle inside the human gut. It is possible that as humans evolved along with nature, our gut system and our immune system evolved to adjust to a constant presence of other gut worms and germs. The developed world’s decision to clean our gut of worms and germs may have been too harsh. Definitely, in MS the presence of worms in the gut makes it far more pleasant for the brain.

Follow your gut: Earlier, it was believed that MS was a caucasian disease when Asian countries reported no MS. Then, in the recent decades, Asians settling in developing countries were developing MS, leading researchers to conclude that MS is a disease of a developed country lifestyle. This, is further proof that the Argentina researchers discovered how the underdeveloped life style may be protective for our human brain.

Respect the hookworm. ‘Follow your gut’ has new meaning.

How to thank the scientists? Dr Correale and Dr Ferez’s original article showing the immune connection between hookworms and MS in 2007 has been cited 91 times. Now, if you want to encourage science of this caliber and in this field, shower these two scientists with your letters and emails. Let them know how much you appreciate them. Read their original article published in 2007. You may encourage them further by emailing them

E-mail: jcorreale@fleni.org.ar

The same scientists have published a 2011 paper showing that patients infected with worms showed significantly less relapses and include updated information. You may want to read their original article published in 2011.

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