Tag Archives: Autoimmune

Colitis and Arthritis share what?


New research is revealing that various types of Arthritis share a common factor with diseases that afflict the gut of younger age groups.  A ten year old, Emma, uses fecal transplants and maintenance doses of medicines to manage her ulcerative colitis.  The idea of fecal transplants, perhaps a more extreme form of probiotics, is to “borrow” the stool from a healthy person with  a healthy balance of intestinal bacteria. The theory behind this is that a healthy person without leaky gut, colitis, Crohns, and irritable bowel syndrome (IBD) may have an environment inside their bowels that supports the growth of natural “good” bacteria, while a person with IBD may lack such natural “good” germs.

What could be common between Arthritis and IBD? Although the ultimate cause of Rheumatoid Arthritis remains elusive, new research suggestions on the role of the gut microbiome is summarized here by scientists Dr. Scher and Dr. Abramson. The gut’s natural bacteria support environment, predisposing genetic factors and environmental triggers are required for disease manifestation. Other scientists have demonstrated that Atherosclerosis was accelerated in “germ-free” mice on a low cholesterol diet. These scientists concluded that identifying the “good” germs and understanding how they exert their beneficial activities, could aid in disease prevention and treatment. Click here to read this scientific study by Dr. Tlaskalova-Hoganova and team.

Colitis and Arthrtis share immunology
It is no surprise that families share arthritic pain, irritable bowel syndrome, and colitis. However, it is a surprise find that the same families share these conditions. Arthritis is an inflammation of the joints and an outside the intestine condition. While arthritis is commonly seen with aging, irritable bowel disease is commonly seen even in children. Of these, arthritis is the most common shared condition found in 25 percent of all irritable bowel disease syndrome sufferers (IBD).  Arthritis and IBD are both autoimmune diseases. They need to be looked at as “co-existing” conditions that influence and interact, while searching for the causes of the auto-immunity.

Prevention is the major goal. The incidence of arthritis in people with IBD is same in men, women and children, which indicates a genetic linkage form of inheritance. Different intestinal diseases like ulcerative colitis, Crohn’s disease, diverticulitis, and celiac disease can lead to different forms of arthritis. Read more.

Ancient Food Habits included Whole Grain. Yet, a gluten - free diet and other life style changes in modern day may keep many free of Irritable Bowel Syndrome and Arthritis. Copyright 2013 (c) Pursue Natural

Ancient Food Habits included Whole Grain. Yet, a gluten – free diet and other life style changes in modern day may keep many free of Irritable Bowel Syndrome and Arthritis. Copyright 2013 (c) Pursue Natural

Learn more about these auto immune diseases by clicking here,  from the Crohn’s and Colitis foundation of America. to read more on the relationship between ulcerative colitis and psoriatic arthritis click here, from Health Central.

Dr. Elena Koles, of the UK Medical system finds it unfortunate that western medical system separates different body systems by ignoring their intricate relationship. Quote

…They need to be looked at as “co-existing” conditions that influence and contribute to one another, rather than two separate, unrelated illnesses. Only a thorough approach that addresses the causes of auto-immunity and recognizes the interaction of IBD and arthritis can ameliorate both diseases….

Unquote. Read more.

Prevention
A personalized approach is best. Pursue Natural prefers that it’s readers are comfortable with the term ‘pharmacogenomic’ which essentially means that if you know how your genes are different from other people, your treatment could in the near future be tailored to the genes that you inherited from your parents. So, assuming that with each article our readers will get quite used to the concept of their own genes being different and unique to require personalized attention to detail, we suggest the following steps:
1) Your treatment must be individualized, by a physician open to a holistic approach combining the knowledge of modern medicine with the following;
2) Physiotherapy and Yoga – individualized routine to keep you pain free and in constant motion; Yoga has helped ease IBD, perhaps by slowing down the breathing rate of anxiety, and relaxing fatigued muscles. Read more.
3) Supplementation – to make up for lack of any minerals and vitamins dictated by modern diagnostics;
4) A comprehensive dietary plan – adding or removing one food item at a time to discover which one causes an auto immune reaction;
5) A comprehensive “emotion review” plan – maintaining a diary of minor or major event each day, because IBD is triggered by an emotional reaction to excitement, fear or unknown fact of life.

Genetics and Shared Immunology of IBD and Arthritis
They share at least the following five genetic factors:

1) Genetic susceptibility to abnormal antigen presentation
2) Aberrant recognition of self, autoantibodies against specific antigens shared by the colon and other 3) extracolonic tissues,
3) Increased intestinal permeability, and
4) An infectious trigger.

The immunological alterations shared are the following:

• E-cadherin expressed highly in gut of patients with IBD and SpA;

• Th1, Th17, and Treg cells active in the intestinal mucosa of patients with IBD and synovial fluid of those with ankylosing spondylitis and SpA;

• Tumor necrosis factor (TNF) alpha is a dominant cytokine in IBD and SpA;

• Interaction of antigen-presenting cells with microorganisms;

• Toll-like receptors TLR-2 and TLR-4; and

• HLA-B27+ and IgA anti-saccharomyces cerevisiae antibodies in CD.

In addition, HLA-B27 transgenic rats develop IBD, psoriasis, enthesitis (inflammation at the sites where tendons or ligaments attach to bone), synovitis, and epididymitis.entation
Abherrant recognition of self
Autoantigens against antigens shared by the colon and other extra colonic tissues
Increased intestinal permeability
Infectious trigger

Read more in medscape.

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A single shared component has been confirmed in allergy and autoimmune diseases


Previous studies had shown that patients with a diverse range of autoimmune diseases often had minor changes in the BACH2 gene. Today’s cutting edge technology allowed scientists to glimpse some of the interactions this gene had with the entire genome to control immune function, says lead author Dr. R. Roychoudhuri. BACH2 plays a key role in the immune system. Although, the intracacy of the immune system remains elusive, it is understood that a healthy immune system knows how to recognize a foreign body and can attack it, to keep a person healthy while in an unhealthy immune system, the body’s own cells or friendly agents are mistaken as “foreign” and attacked resulting in allergy or autoimmune diseases like rheumatoid arthritis and asthma.

This non-profit kids health site lists in the chapter “Health Problems” the many allergy and autoimmune diseases a child may suffer from today. Perhaps, this discovery published in the respected journal Nature might some day help a child and the parent lead a healthier life (Click here to read Nature, June 2, 2013 article).

The Discovery

NIAMS researcher Kiyoshi Hirahara, M.D and colleagues discovered that the Bach2 gene played a key role in regulating the switch between inflammatory and regulatory cells in mice. The loss of the Bach2 gene in specific immune cells caused them to become inflammatory, even under what would be a protective situation. Says a team leader, Dr. Nicholas P. Restifo, “The gene shares its name with the famous composer Bach, since it orchestrates many components of the immune response, which, like the diverse instruments of an orchestra, must act in unison to achieve symphonic harmony”

Potential for Gene Therapy?
The studies were done in mice and will have to be replicated in human clinical trials, which as you know could take time. When the mice lacked the BACH2 gene the mice died within a few months of life.  If the BACH2 gene was introduced into the mice lacking this gene, it restored their immune health. Thus, gene therapy with BACH2, a gene common in patients with allergy and autoimmune disease, restored the immune health of lab mice.

A laboratory research mouse

A laboratory research mouse

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When great scientists go unrecognized by the nobel prize: how should the public make up for that lapse?


Any body who has a family member suffering from an auto-immune disease realizes the importance of research in immune biology. Severe allergy, Multiple sclerosis, Rheumatoid Arthritis, Crohn’s Disease, Lyme Disease, Osteoarthritis, and recently, Diabetes are a list of diseases that are related to a malfunction of the immune order in a body. The body begins to attack it’s own cells believing that it is a “foreign” cell or an invading organism that needs to be destroyed. The degeneration of parts of the body begins leading to specific disease. The New York Times covers the story of two scientists from two different countries who collaborated in the same lab to discover answers to the immune system. Read here to learn about: the seminal contributions of immunologists Charles A. Janeway Jr. (1943-2003) and Ruslan Medzhitov. Their work went unrecognized by the nobel committee. Now, you as the public must begin to award and recognize the scientists you value. Shower them with emails and let them know that you care about their research. Let them feel appreciated. Invite them for talks. Give them free dinners at talks – yes, scientists love that free cookie.

It is also well known that a strong immune system is capable of fighting disease. Monks from Tibet are being researched to teach the world how the mind can control the body’s immune system. A strong, happy person is invariab
ly a healthy person. A sad person, becomes depressed and begins to suffer from all kinds of ailments, many imagined and many real.

Biography:
Click here to read about Prof Charles Janeway. His immunology course at Yale was legendary. He created more immunologists like himself by inspiration.
Click here to read about Dr. Ruslan Medzhitov. He arrived from Russia to work with Dr Charles Janeway, to prove his theory about the two fold immune system.

Prof Charles Janeway

Prof Ruslan Medzhitov

The immune system is two fold: The biological clock of the body controls the innate immune system – just like plants, all humans, animals and birds are conditioned by nature to wake up with the sun, have light exposure of several hours and then off to sleep by sunset or dark. Flowers close, birds stop chirping, animals begin to snore, but humans? Night shift workers have higher rates of illnesses. Could it be a biological clock gone awry?
The innate immune system controls the adaptive immune system which controls how we respond to microbes and environmental insults. When the biological clock is off, the innate immune system is off and since it controls the adaptive immune system, the response to body insult is off. Any wonder why unhappy people or those who work irregular hours feel sicker?

Which scientists should the public honor and thank for researching the innate and adaptive immune system and the way they are connected? You must read the following
A revolutionary idea of how the immune system worked. In vertebrates, two immune systems protect against infection. There’s the evolutionarily older system that all organisms, even plants, have — the innate immune system. There is also another system that evolved relatively recently, the adaptive immune system, which only vertebrates have. Janeway proposed that the innate system detects invading microbes, distinguishes them from everything else and signals the adaptive immune system to move against the intruder.

the authors of the paper did not get a nobel prize and the scientific community is very upset. They felt that the discovery of the toll receptors was worth a nobel prize. Read the New York Times article, “A long journey to the immune system” here.

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High Fructose corn syrup – why would anyone educated still consume it?


Two scientifically researched and published papers show the connection between consumption of high fructose corn syrup and NAFLD. One is a review published in Nature reviews and the other a research paper of a three year study. A third research group says that high fructose corn syrup should be declared an environmental toxin. A fourth paper publised by a team of nutritionists in the American Journal of Clinical Nutrition in 2004, suggest that the obesity epidemic trend since 1970s is closely related to 1000 fold increase in use of high fructose corn syrup in sweetened beverages. This article has already been cited over 800 times by 2012. Click here to read. Why are these international research teams concerned about the rising public health concern of NAFLD?

1) The review postulates that the Western diet which includes excessive fructose may be leading to Nonalcoholic fatty liver disease (NAFLD). Which means that liver damage from excessive consumption of alcohol is expected. However, nonalcoholics are often diagnosed with liver damage. These reviewersblame their western diet which includes beverages sweetened with high fructose corn syrup. The damage is in two steps and the second step can be prevented with antioxidants. However, the western diet does not include or is deficient in antioxidants. The combination of high fructose and lack of antioxidants may be contributing to the most frequent liver disease worldwide – NAFLD. To learn more about the toxic effects of sweeteners you may want to write to one of the authors of this review and ask for a copy of a latest february 2012 article in journal Nature entitled:

Public health: The toxic truth about sugar.

Department of Pediatrics, University of California, San Francisco, California 94143, USA. rlustig@peds.ucsf.edu

2) Another group of researchers (Liver Unit, Ziv Medical Center, Safed, Israel and other colleagues)were perplexed when faced with patients with fatty liver when they did not have the traditional risk factors such as obesity, diabetes and hyperlipidemia. So, they conducted a three year, systematic scientific research study with patients with fatty liver and healthy people (controls) with no fatty liver. They used a validated food questionnaire given by a dietician. They followed the daily intake of food and beverages and sources of added sugar. Their results?

80% of the patients with fatty liver consumed sweetened beverages compared to 20% of healthy people. They included 50grams per day of added sugar to their beverages which was considered excessive by the researchers and 40% of the patients with fatty liver consumed four of more of such beverages which were excessively sweetened. Ultrasound findings revealed mild fatty liver in 44% of the cases to severe fatty liver in 18% of the cases.

Soft drink beverage was the only independent variable able to predict a fatty liver in 82.5% of cases.

If you want to encourage more research on such topics encourage these scientists with your words or funding. Write to them at:

Correspondence: Dr Nimer Assy, Liver Unit, Ziv Medical Center, PO Box 1008, Safed 13100, Israel. Telephone 9-724-682-8441, fax 9-724-682-8442, e-mail assy.n@ziv.health.gov.il or ; Email: assy.nimer@gmail.com

Their conclusion is obvious isn’t it? Change your beverage habit. Unsweeten it. If you cannot stop it yourself, just do not introduce your child to sugar or corn syrup sweetened beverages from childhood. The child will never crave a sweetened beverage and prefer plain water, like our healthier ancestors.

3) A third group of researchers say that high fructose corn syrup depletes ATP and causes uric acid to collect in human bodies. They say it is an environmental toxin. Write to this research team to learn more or if you wish to encourage them for further research on the effect of fructose on renal biology and disease.
Johnson RJ, Sanchez-Lozada LG, Nakagawa T.
Division of Renal Diseases and Hypertension, University of Colorado, Aurora, Colorado 80045, USA.
Email: richard.johnson@ucdenver.edu

Question for our readers: What is used to sweeten beverages today? High fructose corn syrup. Is it better than sugar? If yes, why?

To our readers: If you know of a single healthy benefit of high fructose corn syrup, please share it with our readers.
If you are aware of any human health features improved by substituting sugar used for centuries with high fructose corn syrup introduced in recent decades, please share with our readers.

If you cannot stop yourself from having sweetened beverages, just do not introduce your child to sugar or corn syrup sweetened beverages from childhood. Children develop taste buds as infants. The child will probably never crave a sweetened beverage and prefer plain water, like our healthier ancestors. You may want to write to the pediatricians and scientists listed above and ask why they are concerned of this rising public health threat. The more informed you are, the better you can serve your community and prevent it from facing cripling medical expenses in the near future.

If you liked this, you may also enjoy:

1) Diabetes is an Autoimmune Disease

2) Know your G proteins. One of a series of state-of-the-art articles to be posted here to inform you on the roles of G proteins in human health. Over 30% of medicines today aim for your G proteins for therapy and the newer ones are inter-related to your G proteins. If you want to be current in therapy, you would want to know your G proteins.

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Could anti-CD20 cure Type 2 – Diabetes? Stanford U. and U. Toronto researchers ask today


Researchers who have studied obesity and diabetes asked if both these diseases could be termed autoimmune diseases and  announced today that Type 2 – diabetes can be termed autoimmune disease and it causes obesity.  The human version of anti-CD20, called rituximab, is already FDA-approved to treat some blood cancers and autoimmune disorders. Which may lead to an interesting inquiry: Could this FDA – approved treatment for autoimmune disorders also treat some cases of obesity and all cases of Type 2-diabetes? Published in two articles in Nature medicine, one today and one earlier.

Two excerpts:
Quote

According to co-first author Daniel Winer, MD:

This work will change the way people think about obesity, and will likely impact medicine for years to come as physicians begin to switch their focus to immune-modulating treatments for type-2 diabetes.
Unquote

Quote

Type-2 diabetes is characterized by the gradual development of insulin resistance, which affects the ability of the body to properly metabolize glucose. It’s associated with being overweight, but it can also have a genetic component. Despite the fact that millions of people have type-2 diabetes, the root cause of the insulin resistance is not known. In 2009, Daniel and Shawn Winer showed (also in Nature Medicine; subscription required) that T cells of the immune system were involved. Now they found that another immune cell, called a B cell, also plays an important role.

Unquote

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Type 2 – Diabetes is an Autoimmune disease – say Stanford researchers today; role in Autism?


Stanford researchers, Dr Edgar Engelmann and colleagues redefine Type 2 – Diabetes today as an Autoimmune disease. Autism in children is higher in families and pregnant mothers with Autoimmune diseases. This connection too is being further researched by immunologists studying Autism today.

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