Tag Archives: ASD

SynapDx Corporation lands 15.4 million for Big Autism clinical Study

Geneticists and venture capitalists alike believe that a Massachusetts-based company, SynapDx, can develop the earliest and most informative blood test for autism, and Autism Spectrum Disorders (ASD) using advanced technologies. They specialize in differential expression of certain genes in blood cells that may form the basis of an ASD biomarker. The best diagnostic tests in the near future will combine the knowledge of your genomes, which you inherited from your parents and will pass on to your children, with the technology of computer skills able to handle incredibly large data. A medical technology startup, SynapDx, is currently studying large databases of children who have been clinically diagnosed with autism to discover a shared genomic blueprint. Since all children do not have autism, there might be a particular genomic blueprint among the children that are diagnosed with autism. It is also working on a RNA based blood test to differentiate between patients referred for developmental concerns.  Interested in SynapDx’s clinical study for autism? To learn more click here.

Venture Capital
A group of venture capitalists led by Google Ventures have backed SynapDx autism blood test with 15.4 million, which will help fund the large-scale effort to research 660 children at the same time using advanced computer technology.  The children will be between the ages of 18 months and five years in North America and include children from the Lurie Center of Autism in Massachusetts.  The study will be led by Stan Lapidus, the company CEO. The potential to diagnose children at a very young age, as early as 19 months, is a breakthrough technology currently in clinical trials. Today, an autism diagnosis can be confirmed when a child is 4-5 years, when a child can no longer communicate effectively in society.  This is considered disastrously late.  This infusion of funding will enable the clinical trial to be expanded to 20 sites. The hope is that Google’s expertise with handling big data will aid in pinpointing the role of genome changes in early autism diagnosis.

Autism Diagnosis and Therapy
The earlier a child is diagnosed, the faster a parent may be advised to begin therapy and the use of communication aids. The ipad from Apple company has been a boon for children with ASD helping them to communicate more effectively. More such Apps are also being funded for development to simultaneously pair with therapy of autism.

The role of the gut microbiome has also been recognized as critical since all children with autism have very restrictive eating habits. Research into probiotics and prebiotics are playing a significant role in therapy of autism and ASD. Read “Related Articles” below.

Hopefully, researchers will be able to find a clue as to why parents with multiple sclerosis have children with autism, allergy, and ASD. Is there a genomic blueprint that predisposes a family when exposed to certain unknown triggers? When exposed as a child – ASD; when exposed as an adult – multiple sclerosis. Read “Related Articles” below for discussions on autism, role of aging parents, shank gene, coffee intake of father, G-proteins that try to prevent autism, gut microbiome and good/bad germs, role of Vit-D, and more.

Is Autism observed only in Developed Countries?
Although, this company may only provide a partial answer to the mysterious rise in the number of children developing autism, especially boys, it may give researchers a clue into why children from certain ethnicities develop autism when born in developed countries. Why is autism not observed in developing countries? To read a discussion click here for “Why is Autism observed in America and not in underdeveloped countries?”.  Autism does not discriminate by ethnicity.  It has been observed in Caucasians, Asians, Hispanics and blacks. When children of Somali descent are born in underdeveloped Somalia, they do not develop autism while they do in developed countries like Sweden and USA.  This has led to research on the role of Vitamin D from sunlight in autism, since Somalia is in Africa and has mostly sunny days, while Sweden and USA have far less sunny days, and more indoor activities of an advanced civilization with computer games and television. However, since all children in Sweden and USA have mostly similar indoor activities, why do only some of them have autism? The answer may lie in their genomic blueprint differences and/or exposure to a yet unknown environmental trigger.

Today, developing countries may show more cases of dyslexia or mild autism spectrum disorder. However, as these countries become more like Sweden or USA, will there be more cases of autism diagnosed there too? The answer might be yes, since the autism trigger suspects might be in a developed country lifestyle.  The answer might lie in the way we eat, live, clean, and prevent in an effort to be healthier.  Yet, in that very effort we may unwarily be introducing the triggers like pesticides or herbicides or toxic landfills and spills, that set up local children for autism by damaging the genome of the growing delicate foetus in the womb, depleting our gut of healthy germs that protect symbiotically, or by not understanding all the complex cellular interactions of some of our vaccine components and how they interact with a damaged genome (see below Related Articles).

Related Articles
The Gut Microbiota: your good germ friends to nurture to strengthen your immune system against “Allergy”
Worm Theory: to improve the immune system to fight asthma, multiple sclerosis and more
Autistic child or severely Allergic child with Multiple Sclerosis parent
G proteins: the connector proteins that try to prevent Autism Spectrum Disorder
Know your G proteins: relevant for Allergy, Autism, Aspergers and ASD
Four facts about allergy: parents, children, patients, genes and researchers
Autism in pristine Phu Quoc island of Vietnam – is the rise in numbers simple overdiagnosis?
A single shared component has been confirmed in allergy and autoimmune diseases
World’s largest collection of frozen Autism brains ruined in freezer malfunction
Are we less healthy than our parents and grandparents – both mentally and physically?
Are there any Gays and Lesbians who are autistic?
Why and how to add Calcium in the diet of a person with Autism Spectrum Disorder

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Filed under Genetics, Health, Personalized medicine, Research, Science

Know your G proteins: relevant for Allergy, Autism, Aspergers and ASD

The G protein interconnects several proteins within the cell. Most importantly, it interconnects several proteins to the immune pathway. So, if you have wondered why and how more than one factor could cause the new diseases and allergies we are encountering in recent decades – know your G proteins.

I will write a series of articles on the G protein, Thanks, to a reader ( fitfoodhealthprogram blogger) who asked me to update frequently.

1) They will first describe the G protein and how it functions to take care of you or contributes to disease.    2) Then, they will in a series take each protein and show you how each protein may interact with an environmental factor or a vaccine factor or a bacterial, virus, or fungal protein, or sunlight/Vit D and/or all of them together inside your cells within your body.

You have to realize that all this is in research phase all over the world. So, I will have to be analyzing the most relevant work that succintly states what is important to Allergy, Autism, Aspergers and ASD.

Please, allow for time between articles for some research but also let us know what you want us to expand upon. So, watch out for articles here on how the G protein may hold some answers. It will gather research from all over the world and succintly state what is relevant to our readers. Simple. You simply must know your G proteins.

Irrelevant scientific detail: How do scientists study protein-protein interactions? Here are some links to journal publications in recent years (2005 to current) and a video.
1) Hida and colleagues.
2) Farrell and colleagues.
3) Ai and colleagues. This link takes time to load.
4) Video. Biochemistry and Molecular Biology, Virginia Commonwealth Institute. Extremely good and educational video with a pleasant narrator. Very advanced science content. Invite the speaker to your group to give a presentation and see if these scientists can explain to you about research on receptor interaction.

Research on G protein: Trust me. The answers are critical to your health questions on the new rising issues in recent decades. It is imperative that you understand the importance of interactions of various external signals like pesticides, herbicides, vaccines, common infections, environmental toxins, in combination with your gut signals generated by gut microbials, antibiotics, drugs and food. Only when you understand this major issue, will you be able to demand and fund such protein-protein interaction studies. If you are a journalist, then your role will be to educate your community of readers. Translate what I write into beautiful prose to capture your readers imagination.  As a community, all must begin to understand how different signals interact inside your cell. Simple. You simply must know your G proteins.

Related Articles
Preparing Professors for a student with Aspergers
Mutations in SHANK protein causing Autism in recent years.
National TV news PBS covering Autism and ASD in six series
Autistic or severely Allergic child with Multiple Sclerosis parent – a connection?


Filed under Health, Research, Science

The father, his coffee intake and his aging gene mutations contribute to about 5% of Autism cases

Should women choose younger men to breed with? Yes, for two reasons – coffee intake & male biological clock.
1) Three cups of coffee a day could keep fertility at bay: Dr Andrew Wyrobeck of University of California Berkeley. He advises that a man of any age who drinks even three cups of coffee may have damaged DNA. Other researchers advise that three months before conception, men should restrict their caffeine intake in products that include caffeine. Too many energy products include caffeine. Fathers-to-be need to think before they sip.

The Chemical Nature of Coffee

Their child may inherit the father’s DNA through the sperm, and this DNA may be damaged. Since, the father makes new sperms it is safe to reduce caffeine intake a few months before conception. Once the wife is pregnant, she has to continue avoiding caffeine intake while the father can get back to caffeine intake. Men have biological clocks. Sketch of Old Man Enjoying his coffee

2) The Aging Man fathers about 5% of Autistic Spectrum children
As the father ages his DNA is damaged spontaneously bombarded by toxins he is exposed to in a developed world lifestyle. The older the father gets, the more DNA is damaged and the chances of his sperms passing these on to produce a child with birth defects increases. Of course, the damaged DNA carrying sperm has to find an egg, and the longer the father delays in allowing his sperm to seek an egg, the more chances of increasing DNA damage in his progeny. Given these chances currently are only 5% for unknown reasons. These mutations in the fathers gene are new, which means that his father or grand father did not have this DNA damage. But his son may inherit them and if he does seek a woman to breed with, he too will pass it on to his child. The older father, thus, procreates a damaged dynasty with a 5% chance.
For the peer reviewed journal article on Age of father, new spontaneous gene mutations and relation to a percentage of ASD cases click here.

Many Energy Drinks contain Caffeine

Now, add three cups of coffee to an older father about to breed and what do you get? An Older Father and Child

Related Articles
Coffee and Caffeine FAQ
CBS news covers older fathers and autistic child
Autism prevention blog – Father babies 24-34

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Filed under Health, Research, Science