Colitis and Arthritis share what?


New research is revealing that various types of Arthritis share a common factor with diseases that afflict the gut of younger age groups.  A ten year old, Emma, uses fecal transplants and maintenance doses of medicines to manage her ulcerative colitis.  The idea of fecal transplants, perhaps a more extreme form of probiotics, is to “borrow” the stool from a healthy person with  a healthy balance of intestinal bacteria. The theory behind this is that a healthy person without leaky gut, colitis, Crohns, and irritable bowel syndrome (IBD) may have an environment inside their bowels that supports the growth of natural “good” bacteria, while a person with IBD may lack such natural “good” germs.

What could be common between Arthritis and IBD? Although the ultimate cause of Rheumatoid Arthritis remains elusive, new research suggestions on the role of the gut microbiome is summarized here by scientists Dr. Scher and Dr. Abramson. The gut’s natural bacteria support environment, predisposing genetic factors and environmental triggers are required for disease manifestation. Other scientists have demonstrated that Atherosclerosis was accelerated in “germ-free” mice on a low cholesterol diet. These scientists concluded that identifying the “good” germs and understanding how they exert their beneficial activities, could aid in disease prevention and treatment. Click here to read this scientific study by Dr. Tlaskalova-Hoganova and team.

Colitis and Arthrtis share immunology
It is no surprise that families share arthritic pain, irritable bowel syndrome, and colitis. However, it is a surprise find that the same families share these conditions. Arthritis is an inflammation of the joints and an outside the intestine condition. While arthritis is commonly seen with aging, irritable bowel disease is commonly seen even in children. Of these, arthritis is the most common shared condition found in 25 percent of all irritable bowel disease syndrome sufferers (IBD).  Arthritis and IBD are both autoimmune diseases. They need to be looked at as “co-existing” conditions that influence and interact, while searching for the causes of the auto-immunity.

Prevention is the major goal. The incidence of arthritis in people with IBD is same in men, women and children, which indicates a genetic linkage form of inheritance. Different intestinal diseases like ulcerative colitis, Crohn’s disease, diverticulitis, and celiac disease can lead to different forms of arthritis. Read more.

Ancient Food Habits included Whole Grain. Yet, a gluten - free diet and other life style changes in modern day may keep many free of Irritable Bowel Syndrome and Arthritis. Copyright 2013 (c) Pursue Natural

Ancient Food Habits included Whole Grain. Yet, a gluten – free diet and other life style changes in modern day may keep many free of Irritable Bowel Syndrome and Arthritis. Copyright 2013 (c) Pursue Natural

Learn more about these auto immune diseases by clicking here,  from the Crohn’s and Colitis foundation of America. to read more on the relationship between ulcerative colitis and psoriatic arthritis click here, from Health Central.

Dr. Elena Koles, of the UK Medical system finds it unfortunate that western medical system separates different body systems by ignoring their intricate relationship. Quote

…They need to be looked at as “co-existing” conditions that influence and contribute to one another, rather than two separate, unrelated illnesses. Only a thorough approach that addresses the causes of auto-immunity and recognizes the interaction of IBD and arthritis can ameliorate both diseases….

Unquote. Read more.

Prevention
A personalized approach is best. Pursue Natural prefers that it’s readers are comfortable with the term ‘pharmacogenomic’ which essentially means that if you know how your genes are different from other people, your treatment could in the near future be tailored to the genes that you inherited from your parents. So, assuming that with each article our readers will get quite used to the concept of their own genes being different and unique to require personalized attention to detail, we suggest the following steps:
1) Your treatment must be individualized, by a physician open to a holistic approach combining the knowledge of modern medicine with the following;
2) Physiotherapy and Yoga – individualized routine to keep you pain free and in constant motion; Yoga has helped ease IBD, perhaps by slowing down the breathing rate of anxiety, and relaxing fatigued muscles. Read more.
3) Supplementation – to make up for lack of any minerals and vitamins dictated by modern diagnostics;
4) A comprehensive dietary plan – adding or removing one food item at a time to discover which one causes an auto immune reaction;
5) A comprehensive “emotion review” plan – maintaining a diary of minor or major event each day, because IBD is triggered by an emotional reaction to excitement, fear or unknown fact of life.

Genetics and Shared Immunology of IBD and Arthritis
They share at least the following five genetic factors:

1) Genetic susceptibility to abnormal antigen presentation
2) Aberrant recognition of self, autoantibodies against specific antigens shared by the colon and other 3) extracolonic tissues,
3) Increased intestinal permeability, and
4) An infectious trigger.

The immunological alterations shared are the following:

• E-cadherin expressed highly in gut of patients with IBD and SpA;

• Th1, Th17, and Treg cells active in the intestinal mucosa of patients with IBD and synovial fluid of those with ankylosing spondylitis and SpA;

• Tumor necrosis factor (TNF) alpha is a dominant cytokine in IBD and SpA;

• Interaction of antigen-presenting cells with microorganisms;

• Toll-like receptors TLR-2 and TLR-4; and

• HLA-B27+ and IgA anti-saccharomyces cerevisiae antibodies in CD.

In addition, HLA-B27 transgenic rats develop IBD, psoriasis, enthesitis (inflammation at the sites where tendons or ligaments attach to bone), synovitis, and epididymitis.entation
Abherrant recognition of self
Autoantigens against antigens shared by the colon and other extra colonic tissues
Increased intestinal permeability
Infectious trigger

Read more in medscape.

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