Monthly Archives: June 2013

ADI collaborates to develop a hand-held device to use during disease outbreaks


Antigen Discovery Inc.,(ADI) is developing hand-held point-of-care (POC) diagnostics to meet a vital need. First responders during major disease outbreak need a portable device, that is easy to use, and will give a prompt answer to the question, “What is making so many people very sick?” The biotech company, ADI, is collaborating with the academic team from a Biomedical Department of the Henri Samueli School of Engineering to embark on this project with the goal of developing a device, probably compatible with our current hand-held-phones, with the necessary portability, ease-of-use, and prompt sample-to-answer times.  Towards this purpose, ADI has received a Phase I SBIR Grant, which shows confidence, recognition and support of their key technology by leaders in this field. Hopefully, this small, portable device will work in a field environment during a disease crisis and also be a financial success. Such a collabortion of the best of biotechnology academic and development & marketing capabilities, might save many lives.

A Reactive Antigen Microarray (40, 80, 160, or 400 arrays/pkg) for quick Malaria detection

A Reactive Antigen Microarray (40, 80, 160, or 400 arrays/pkg) for quick Malaria detection

The technology utilizes proteome microarrays in immune response profiling. The diagram on their website details very simply their basic technology of antigen discovery for vaccine and diagnostic development. Proteins are printed on a microarray – these proteins are from the known infectious organisms. Antibodies from the patients’ blood will bind to a few of these proteins if they are infected with any of those known infectious organisms. They have the basic infectious agent disease technology. What they do not have is the technology required to get this information quickly, at a field site, where there might be hundreds of people dying mysteriously or getting very sick after a natural disaster from a mysterious disease. For this they turned to a collaboration with an advanced engineering biomedical department.

A team led by Abraham Lee Chair, Biomedical Engineering Director, Micro/Nano Fluidics Fundamentals Focus Center The Henry Samueli School of Engineering University of California, Irvine provided them a solution.

The Henry Samueli School of Bioengineering, Irvine, CA collaborating with Antigen Discovery Inc., CA

The Henry Samueli School of Bioengineering, Irvine, CA collaborating with Antigen Discovery Inc., CA

Dr Lee’s team’s goal is to unveil biological events such as cell signaling pathways, genetic mutation processes, or the immune responses to pathogens, with a method to generate large-scale, multifunctional nano-bio interfaces with readout and control. Professor Lee’s research group is developing integrated microfluidic platforms with the goal of generating programmable synthesis of multifunctional nanotransducers. One of the research interests is micro devices for distributed surveillance in liquid-based environments.

Professor Abraham “Abe” Lee’s research interest focuses on the development of integrated micro and nano fluidic chip processors for the manipulation and self-assembly of biomolecules and other synthesized nanoparticles. These integrated chip processors will also be designed for the sample preparation of biological fluids to extract the required ingredients for on-chip transducers. Applications for these fluidic processors include programmable precision production of biological reagents for nanomedicine, biomolecular nanosystems that utilize biophysics principles, and platforms to perform controlled studies of molecule-molecule/cell-molecule interactions.

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Throat cancer: What, Why, Who and Everything you should know, before oral sex


Throat cancer is one of the many kinds of Head & Neck cancers. When Hollywood actor, Michael Douglas, was diagnosed with stage 4 throat cancer, he brought this disease, usually discussed in hushed tones to the limelight. He used his estimated worth of $200 million to get the best attention and cure for his cancer, which fortunately could be cured. His ordeal with throat cancer was portrayed on the popular TV show, “The Oprah Winfrey Show”. His portrayal of his “persistent sore throat” opened up the discussion of this particularly treacherous, fast developing cancer.  This Oscar winning actors Actor Michael Douglas’ comments about throat cancer have thrown a spotlight on risks from HPV during oral sex. Michael Douglas suggests oral sex caused his throat cancer.

Sex in Ancient Rome

Sex in Ancient Rome

“I’ll never forget,” Michael says. “All he did was put a tongue depressor on my tongue. I just looked—I saw the look in his eye. He pulled back, and he looked at me, and said, ‘Well, I guess we’re going to need a little biopsy on that.'”. He is now cancer free.

Read more: http://www.oprah.com/oprahshow/Hollywood-Legend-Michael-Douglas-Tells-All/2#ixzz2WfE3Dzp3

Throat cancer can kill
Many throat cancer patients are not this fortunate; they may not be diagnosed in time to survive this quick progressing scrouge of the mouth, larynx and voice box. It kills more men than women. In recent times there has been an alarming rise in throat cancer, especially among men. There are many risk factors for throat cancer. Among them oral sex and the biological microorganism, HPV, are suspected to play an increasing role in recent years. HPV or the Human Papilloma Virus, has been shown to have an association with various cancers of the neck of both men and women, in addition to cancers of the cervix in women. During oral sex, the micro-organism, HPV might be transferred between males and females, or between males and males, or between females and females. HPV does not discriminate.  HPV is a common cause of sexually transmitted disease (STD) and is spread during unprotected sex with an infected partner. Read more.

Symptoms
Listed below are some of the general symptoms and warning signs of head and neck cancer listed by Memorial Sloan Kettering Cancer Center of New York, which treated and cured actor Michael Douglas of his throat cancer, after an attentive Canadian doctor diagnosed his “persistent sore throat” needed a biopsy.
* blood in the sputum
* persistent sore throat
* persistent hoarseness or a change in the voice
* persistent pain in the neck, throat, or ears
* difficulty chewing, swallowing, or moving the jaws or tongue
* numbness in the tongue or other areas
* a lump or swelling in the neck

Throat cancer is the cancer of the mouth, larynx, voice box, thyroid
Throat cancer is not a medical term. In hospitals it is under the term Head and Neck cancers. The medical name for the throat is the pharynx. The easiest way to think of this is as a passage that makes sure food and drink go in one direction (down the food pipe). Cancers are treated according to where they started and the type of cell they started from. The treatment for mouth cancer will not be the same as treatment for cancer of the voice box. Each year, approximately 48,000 Americans are diagnosed with a head or neck cancer (not including skin cancers that occur in the head or neck). These tumors account for up to 5 percent of all cancers in the US.

Oral Cancer
Cancer of the oral cavity (mouth) is the most common type of head and neck cancer. Nearly 30,000 new cases of oral cancer are diagnosed in the US each year. Oral cancer can begin in the lips, the gums, the area behind the molars or wisdom teeth, the inside of the lips and cheeks, the floor and roof (hard palate) of the mouth, and the front of the tongue. Most oral cancers arise in the tongue, the lip, the floor of the mouth, and the minor salivary glands. The rest are found in the gums and other sites.(Read more).
Your dentist is your first line of prevention – most oral cancers are first detected by the dentist!

Laryngeal Cancer
The cancer that arises in the voice box (larynx) — is the second most common type of head and neck cancer. An estimated 12,000 new cases of laryngeal cancer are diagnosed in the US each year. The vast majority of laryngeal cancers occur in men. People with aplastic anemia, a blood disorder associated with certain hereditary conditions, exposure to chemical inhalants like asbestos, deficiency in vitamins A and E, may have a higher risk of developing laryngeal cancer. The most common symptoms of laryngeal cancer include hoarseness, ear pain, a neck lump in the neck near the adam’s apple and difficulty swallowing. Read more.

Pharyngeal (Throat) Cancer
Prior infection with human papillomavirus (HPV) is also a particularly strong risk factor for this cancer site (Read more). The cancer of the pharynx or throat is in three areas of the throat:
– uppper part of the throat, nasopharynx
– middle part of the throat, oropharynx
– bottom part of the throat, hypopharynx
An estimated 11,800 people develop pharyngeal cancers in the US alone, but nasopharynx cancer is much more common in Asia, the Mediterranean area, and Africa than in the US. A lump in the throat is the most common symptom with nosebleeds as a frequent symptom. The living with mouth and oropharyngeal cancer pages cover coping with your diagnosis and the possible effects of cancer and treatment on your appearance, diet, breathing, speech and sex life. Read more.

Throat cancer is squamous cell cancer
Squamous cell cancer is the type of cancer which remains restricted to a specific region. Read more.

Prevention
This cancer is considered preventable. Read more. Visits to the dentist is the first line of screening for oral cancer! A poor diet, a weakened immune system and prior exposure to the Human Papilloma virus (HPV) among other exposure factors that are preventable.

Screening
An annual examination for such cancers of the Head and Neck is highly recommended if you suspect a risky lifestyle factor. The annual visit to the dentist is an additional recommended screening for oral cancer. The Memorial Sloan Kettering Cancer Center of New York, hosts a free screening for this cancer every spring funded by The Yul Brynner Foundation. Do check your local hospitals. They too may host free screenings, or dental visits or group chats with people having similar symptoms and worries. Physicians have found that seeking out people who share your similar concerns about this cancer has helped in therapy.

KEEP YOUR THROAT PRETTY!

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War against the aging effects of menopause – Three activities which help


Is this worth signing up for? “Plus, receive your FREE Bonus Report, Living to 100: What’s the secret?” promises Harvard University’s free newsletter, HEALTHBeat. What are the chances that you might live until you are one hundred years old? Pretty good, if you allow every creaking, malfunctioning organ inside your body to be replaced. The combined features of personalized medicine, 3-D printing and organ tissue culture are achieving true leaps in science.

However, men and women’s aging remains a mystery. The hormone Estrogen, which provides vitality and fertility to young women works with a few other hormones and minerals like Calcium in a rather mysterious manner. It is apparently controlled by a master, age – controlled switch, which decides when a woman will begin to decline cognitively. Yes, menopause controls when a woman becomes “foggy”, in a manner which is unclear, since women in some cultures never become “foggy”.

So, here we are attempting to discuss modern scientific discoveries that prevent aging, post – menopausal women from becoming “foggy”. Chances are, if your mother or grandmother is not “foggy” you have inherited good aging genes and need read no further. However, if you are aware of declining cognitive function in your gene pool, then perhaps, you might want to be aware of latest scientifically backed products claiming to reverse this decline.

Are there any effective products in the market today to revert effects of menopause?

Scientists are specializing in different parts of the body where these hormones of health and vitality may play a role. The brain, or the Neurogenesis and gender, is a major frontier being explored. A Rockefeller scientist, Dr. Bruce S McEwen, has devoted his career to this and is of the opinion we have a long way to go. He showed as early as the year 1999 that the hormone Estrogen had an effect on the brain. Estrogen changes brain structure, learning and memory he discovered. In the year 2004, Dr McEwen’s team published scientific evidence of a specific area in the brain where Estrogen plays a role – Estrogen controls dendritic spines formations and synaptic complexes. Estrogen may be associated with enhancement of hippocampal-dependent memory.

Physical activity, social contacts, intellectual pursuits
The conclusion even today from Dr. McEwen is that physical activity, social contacts, intellectual pursuits will do far more to help your personal war against the aging effects of menopause than any current market therapy available. They have a similar effect on stimulating the dendritic spines and synaptic connections of the brain and scientists who have devoted their career to this field have no explanation for this. Psychologists studying the aging woman’s brain activity say it is a myth that woman will definitely lose their cognitive function as they age because many women have perfectly great cognition, some even better than many middle – aged people.

Three things an aging woman will definitely benefit from:
1) Physical activity – exercise daily to invigorate your brain
2) Social contacts – seek out people and have conversations and relations; laugh and cry
3) Intellectual pursuits – learn a new subject every week and “master” it
All three above activities are known to stimulate the hippocampus with no detrimental side-effects.

Estrogen unknowns
Why does Estrogen control the brain? How does Estrogen control the brain? What controls Estrogen? When will we discover this master switch that regulates Estrogen and controls a woman’s moods and cognitive functions?

Provera
The hormone Provera has been prescribed along with Estrogen to menopausal women. However, Provera has side effects. The above discussion has shown how little we understand the master menopausal hormone, Estrogen. We understand Progesterone even less. Provera is an attempt to recreate Progesterone artificially. The side effects are considerable and the risks and benefits must be considered with the long-term view in mind. In brief, Provera, the artificial form of Progesterone, counteracts the beneficial effects of Estrogen therapy, when in combination therapy. Which means you might negate any positive effect of Estrogen therapy. This process, is incompletely understood, but if you have a choice, AVOID Provera, until studies satisfy and assure you of the long-term benefits.

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Lead contamination in rice studies could not be replicated


Independent laboratories have not been able to confirm the levels of lead contamination in imported rice reported recently (April 2013) by various news agencies like BBC,CBS, Science Daily.  Some of the highest levels were found in baby food, reported the scientists, at the 245th National Meeting & Exposition of the American Chemical Society. Since FDA and independent laboratories have not been able to confirm these findings yet, scientists led by Dr. Tongesayi’s team, which is with Monmouth University in N.J., have delayed publishing their findings. To read more about “Study Linking Rice to Elevated Lead Levels Withdrawn” in FoodProductDesign.com, you may click here, and “Study of lead levels in Rice under Scrutiny” in BBC News Science & Environment.

Lead has been recognized as a poison for thousands of years, but the profound impact that chronic exposure to even low levels of lead can have on developing children only became widely recognized in the United States in the 1970s.

A rice field in Korea

A rice field in Korea

The Lead Contamination in Rice Study

The US imports 7% of its rice and 65% of this rice is from China, Taiwan, India, Italy, Bhutan, Israel, Czech Republic. Dr Tsanangurayi Tongesayi of Monmouth University in New Jersey, US, and his team tested for heavy metal contamination in rice, especially lead, from local food stores in New Jersey. They were concerned by the higher lead levels and speculated that daily lead exposure was higher. These levels were two to twelve times higher than what FDA finds a health concern. They concluded these levels could potentially cause harm to health. To read the full BBC News reported article you may click here.

Children would be most at risk in groups that ate more rice than any other grain. Asians and Latinos are rice preferring societies. Other societies drink rice milk to substitute for milk (lactose or casein) intolerance and rice cakes to substitute for wheat (gluten) or oat intolerance.

LEAD POISONING AND NEUROBEHAVIORAL PROBLEMS
An active area of research is why different people react differently to similar levels of lead exposure. This variability is the reason why the Centers for Disease Control (CDC) always refers to a child as having an “elevated” blood lead level – i.e., a level above which symptoms are frequently seen in children – as opposed to calling a child “lead poisoned”. There is clear evidence even very low levels of lead are harmful to children’s health. In addition, studies suggest individuals who suffer from chronic lead poisoning during early childhood are more likely to behave violently and engage in criminal behavior later in life. Hilary A. Godwin, Ph.D. Professor, UCLA Department of Environmental Health Sciences, article summarizes our understanding of the effects of lead exposure on children’s health, and explains why the focus of the pediatric and environmental health communities has shifted toward prevention of lead poisoning.

A SHIFT TOWARD PRIMARY PREVENTION
An important take-home message from all of these studies of the effects of lead poisoning is that it is better to prevent lead poisoning from happening in the first place than to treat lead poisoning after it has occurred, an approach often referred to as “primary prevention of lead poisoning”. Possible known sources of lead exposure are lead house paint, and contaminated soil.

Diet to lower absorption of lead

Diets rich in nutrients, such as iron, calcium, and zinc, and low in fat have been shown to reduce the amount of lead that children (and adults) absorb into their bodies for a given exposure. There is an interesting relationship between zinc and protein — people who do not include a sufficient amount of protein in their diets do not have sufficient amounts of zinc in their body. The body can get zinc from protein-rich foods such as nuts, pecans, pumpkin seeds, and sunflower seeds. The best sources of zinc include milk, yeast, peanuts, potato, whole wheat bread, cheese, beans, yogurt, brown rice, wholegrain cereals, etc. You may read more about such a zinc rich diet by clicking here for this Newsmax Feb 2011 article.

Interestingly, the 1999 Nobel Prize in Medicine was for discovering that humans need protein to absorb minerals like zinc. Which means a healthy diet must include protein and minerals like zinc.

Ironically, rice plants may come naturally fortified with zinc. One might speculate: could rice naturally fortified with zinc prevent detrimental effects of lead exposure through lead contaminated rice? Rice plants grown in zinc deficient soils suffer from “Khaira” disease, or zinc deficiency. You may read more about the Khaira zinc deficiency disease of rice in India by clicking here, for a 1985 journal article by scientists Chatterjee and Mandal, in the Department of Agricultural Chemistry and Soil Science, Kalyani, India. Total dietary intakes of zinc of the people from Japan, Indonesia and China, where rice is the primary cereal grain, was higher than the recommended dietary allowance of daily zinc intake from foods by the American standard diet (15 mg/person). You may click here to read more about the zinc levels of rice in these three countries. Needless to add, perhaps, this natural level of zinc in rice can protect upto a certain threshold of lead contamination in rice, and has been developed by ancient societies that consume rice over the millennia.

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The first Phenome Center established to research interactions between genes and the environment


Certain people become more susceptible to environmental toxins and food allergens than other people exposed to the very same factors. Why is that? How are some people completely healthy even after they eat food that makes other people very sick? Why are some children in the autistic spectrum disorder growing up in the same environment and eating the same food as their healthy neighbors children?

To research the answers to these growing questions in an increasingly post – industrial modern society used to extremely convenient modes of transportation and fast food, a large scale multi-disciplinary approach is required.  Joining together in this effort are  the MRC-NIHR Phenome Centre, which opened recently in the United Kingdom, with a collaboration between Imperial College London, King’s College London and analytical technology companies Waters Corporation and Bruker Biospin.

The center has ten million pounds of funding for the first five years. However, if you wish to support such relevant research do not hesitate to contact the institute. Studying the phenome will help determine how diet, lifestyle, the environment and genes combine to affect biochemical processes that lead to disease.

Professor Frank Kelly, co-investigator at the Centre and director of Analytical and Environmental Sciences Division at King’s College London, said, “This technology is already in use in medical research but only on a small-scale. With the creation of this new facility, it will now be possible to get a complete and accurate biological read-out of thousands of individuals.” Reported in  Pharmabiz, June 13, 2013. Instruments of the highest degree of sophistication will detect the different types of bacteria naturally occurring in the gut, which can influence our health. Read this previous article on how hook worms can cure multiple sclerosis in some patients or this previous link on “the worm theory and how it could strengthen the immune system”.

The Centre will also include a state-of-the-art international training facility. There are no limits to the breakthroughs in health we might see as a result of this visionary, large data work approach at the NIHR-MRC Phenome Centre.

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Odors can identify and differentiate three stages of melanoma


The human skin produces numerous airborne chemical molecules known as volatile organic compounds, or VOCs, many of which are odorous. “There is a potential wealth of information waiting to be extracted from examination of VOCs associated with various diseases, including cancers, genetic disorders, and viral or bacterial infections,” notes George Preti, PhD, an organic chemist at Monell who is one of the paper’s senior authors.

A Melanoma nodule (From National Cancer Insitute)

A Melanoma nodule (From National Cancer Insitute)

Philadelphia based, The Monell Chemical Senses Center has an innovative way of detecting melanoma through a unique odor signature detection technique.  Tiny, nano-sized tubes can be bioengineered to recognize among other targets, a variety of odor factors which could evaluate the stage of a disease progression. Before this discovery can be brought to a doctor’s office, a portable measuring device has to be invented.

Examine your own skin regularly to know what is normal for you says Melanoma Research Foundation. Moles might resemble Melanoma but are usually benign or non-cancerous.  It is safer to take annual photos of your moles to detect any abnormal rate or changes.

If you wish to fund or encourage any aspect of this research do not hesitate to contact the researchers at:

George Preti, Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA

You may want to read the original scientific article: Jae Kwak, Michelle Gallagher, Mehmet Hakan Ozdener, Charles J. Wysocki, Brett R. Goldsmith, Amaka Isamah, Adam Faranda, Steven S. Fakharzadeh, Meenhard Herlyn, A.T. Charlie Johnson, George Preti. Volatile biomarkers from human melanoma cellsJournal of Chromatography B, 2013; DOI: 10.1016/j.jchromb.2013.05.007

How to self – diagnose Melanoma?
What is melanoma? Mayo Clinic of Cleveland has a slide show on how to identify and self examine for melanoma, a skin cancer.

Melanoma Research Foundation has good photos on what Melanoma might look like.

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A single shared component has been confirmed in allergy and autoimmune diseases


Previous studies had shown that patients with a diverse range of autoimmune diseases often had minor changes in the BACH2 gene. Today’s cutting edge technology allowed scientists to glimpse some of the interactions this gene had with the entire genome to control immune function, says lead author Dr. R. Roychoudhuri. BACH2 plays a key role in the immune system. Although, the intracacy of the immune system remains elusive, it is understood that a healthy immune system knows how to recognize a foreign body and can attack it, to keep a person healthy while in an unhealthy immune system, the body’s own cells or friendly agents are mistaken as “foreign” and attacked resulting in allergy or autoimmune diseases like rheumatoid arthritis and asthma.

This non-profit kids health site lists in the chapter “Health Problems” the many allergy and autoimmune diseases a child may suffer from today. Perhaps, this discovery published in the respected journal Nature might some day help a child and the parent lead a healthier life (Click here to read Nature, June 2, 2013 article).

The Discovery

NIAMS researcher Kiyoshi Hirahara, M.D and colleagues discovered that the Bach2 gene played a key role in regulating the switch between inflammatory and regulatory cells in mice. The loss of the Bach2 gene in specific immune cells caused them to become inflammatory, even under what would be a protective situation. Says a team leader, Dr. Nicholas P. Restifo, “The gene shares its name with the famous composer Bach, since it orchestrates many components of the immune response, which, like the diverse instruments of an orchestra, must act in unison to achieve symphonic harmony”

Potential for Gene Therapy?
The studies were done in mice and will have to be replicated in human clinical trials, which as you know could take time. When the mice lacked the BACH2 gene the mice died within a few months of life.  If the BACH2 gene was introduced into the mice lacking this gene, it restored their immune health. Thus, gene therapy with BACH2, a gene common in patients with allergy and autoimmune disease, restored the immune health of lab mice.

A laboratory research mouse

A laboratory research mouse

Related Article

A multiple sclerosis parent with autistic child
Know your G protein – for autism, allergy, aspergers and ASD

G proteins – the connector proteins that try to prevent autism spectrum disorder
Do anorexics and autism spectrum disorder share any common characteristics?

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Autism in pristine Phu Quoc island of Vietnam – is the rise in numbers simple overdiagnosis?


Phu Quoc is a pristine, mountainous, Vietnamese island, surrounded by sun-drenced beaches and clear, blue water, about 70 miles off the coast of Cambodia.  Most of the island is covered by Phu Quoc National Forest. The main industries are plantations and fish sauce. It hosts the annual Vietnam Kennel Association (VKA) Phu Quoc National Dog Show. The Phu Quoc Ridgeback is a native dog breed with web feet, an island treasure that has thrived on Phu Quoc Island since the 19th century. Yet, Aeir Talk, an App for a communication device for autistic kids, believes that this island would benefit from knowledge that a device to assist Autistic kids exists (Click here for advertisement, by scrolling below to a post by Jav123 on Mar 2012). Why should this remote island be interested in an Autism device? Read about the naval history of this island in Vietnam by clicking here.

Should men be more careful about protecting their sperm before they begin to make babies? Fathers provide the sperm and the mother, as you know, provides the egg and when the egg is fertilized by the sperm the baby results. There is increasing evidence that the father or grandfather may contribute a new genetic change that might be inherited; such a new genetic change when perhaps exposed  to an otherwise harmless environmental pollutant becomes a “toxin” to this child carrying this new genetic change. The grandfather may even pass this new genetic trait through his daughters. Fathers have been cautioned against excessive coffee drinking three months before making babies. Perhaps fathers need to avoid exposure to environmental triggers too? Maybe, strategic research would help to pinpoint such triggers and help prevent more autism related to exposures of potential fathers in the future. History cannot be changed but our society is quite capable of taking action when inspired. Read Lynne Peeple’s Huffington Post article (May 2012) on the rising rates of autism by clicking here.

Rise of Autism in some countries

Here is an article detailing and discussing the rise of autism in Vietnam. Among Asian countries, this country appears to have far higher rates. Is it simply a matter of higher diagnosis? You may click here to read this brief article (March, 2013) in a China Weekly newspaper, on the city of Hanoi, Vietnam. This may be of interest to international researchers of Autism. Why Hanoi? Hopefully, even searching for an answer in Hanoi will lead researchers closer to factors that might trigger ASD.

Is the rise of Autism simply overdiagnosis?

There is no doubt that some cases of ASD are simply over diagnosed. However, once you have been in the same room, train, class room, event with a kid (mostly boys) with even an average level of ASD or worse autism, even as a non – psychologiist you will know that the child needs help. The uneducated citizen might request that this child be punished for “misbehavior” or request this child “shut-up” or “stop shuffing people or yelling”. Those aware of ASD will realize this is a child with autism or aspergers and intervene on behalf of the child. As those educated about this growing issue of ASD know, this child’s mind is fully knowledgeable and understands but cannot control his/her actions. Give the child an ipad and this child will communicate to those in the room and may even apologize but unable to stop the movement or noise causing the discomfort to the public. As a society, together we can help prevent future suffering. We are losing our boys and some girls. Your opinion matters. If you suspect any factor that could be contributing to the growing rise of autism/asperbers/allergy/ASD do not hesitate to share. None of us want to lose the advantages of modern conveniences. We cannot imagine life without cars, trains, and automobiles, aeroplanes and modern industry, modern agriculture and green lawns without weeds. Yet, since progress must come with side effects, let’s discover how to live together safely, among these industrial advantages. We are quite capable of dealing with and preventing side effects.

Which other countries have higher rates of Autism than their neighboring countries?

Which countries have similar health and hospital facilities and yet have higher levels of Autism? There have been indications that areas with higher automobile oil manufacturing chemical waste, may have higher rates of autism or childhood leukemia. Some elementary classrooms in such locations have several children arriving to school in wheelchairs with juvenile rheumatoid arthritis or many parents waiting together outside a local pediatric hospital which had not timely diagnosed their infants with childhood leukemia; four year olds were dying. Autism aids are in many such classrooms. Is there a connection? Can some action steps put in place protective and preventive features perhaps in the local water system or the herbicide spraying system in home lawns to protect possible harm to the sperm and egg? Would there be a connection with such chemical waste and a carrier of the new genetic inherited trait? If you have answers or suggestions do share. 

Related Article:

Why is there little Autism in under-developed countries?

The G-proteins, the connector proteins that try to prevent autism spectrum disorder.

Phu Quoc – Vietnam’s largest island and home of the Phu Quoc National Forest

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To make your own filaments for cheaper 3D printing: Invention of Lyman Filament Extruder II


An 83 year old inventor of the Lyman Filament Extruder II, Hugh Lyman, who in 1976 wrote in The Computerworld magazine about IBM 5100, an early 55 lb “portable computer” may have solved a major source of expense for those interested in 3D printing. The 3D printer has been called “The emerging gadget which may very well change everything” by Time Magazine in 2013. A desk-top model of the 3D printer may be available for $500.00.

Zach Kaplan, CEO of Inventables (left), presents a commemorative giant check to inventor and competition winner Hugh Lyman on March 2, 2013 at Seattle's MakerHaus Read more: http://techland.time.com/2013/03/04/how-an-83-year-old-inventor-beat-the-high-cost-of-3d-printing/#ixzz2VTgqPZsF

Zach Kaplan, CEO of Inventables (left), presents a commemorative giant check to inventor and competition winner Hugh Lyman on March 2, 2013 at Seattle’s MakerHaus
Read more: http://techland.time.com/2013/03/04/how-an-83-year-old-inventor-beat-the-high-cost-of-3d-printing/#ixzz2VTgqPZsF

Answering a call for an invention that would solve the problem of expensive filaments required for 3D printing, Hugh Lyman submitted two entries. More than 12,000 3D printing enthusiasts from around the world have already downloaded the plans of his two extruders. Atleast one 3D company Lulzbot, plans to sell a pre-assembled version. The second entry is a cheaper to make and use version, and won the $40,000 Inventables award, set up by Zach Kaplan, CEO of Inventables. Click here to see Time Magazine’s video on how the Lyman’s winning extruder works, photos of Hugh Lyman, Zach Kaplan, and Lyman’s two entries, with an excellent article on the inventor. The two plans are:

1) First entry – Lyman Filament Extruder which can turn pellets into filaments but costs more than $250.00
2) Second and winning entry – Lyman Filament Extruder II, with a few of the parts changed from the first design entry to be prized under $250.00; the judges agreed that he was the winning inventor of the “Desktop Factory Competition”.

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Can oral sex cause throat cancer? Yes, and for more men than women


HPV, or the Human Papillomavirus, has been shown to be associated with cervical cancer, a STD fact. Actor Michael Douglas, recently announced that he was recovering from a type of throat cancer that may have been associated with HPV. Naturally, this site decided to to search for the scientific fact behind this statement and found the following upto date information of oral cancer from HPV. The Centers of Disease Control says that each year in the U.S., HPV is thought to cause an estimated
1,700 oropharyngeal cancers in women,* and
6,700 oropharyngeal cancers in men.*
*Note: Other factors, notably tobacco and alcohol use, may also play a role with HPV to cause these cancers. Oropharyngeal cancer means throat cancer.

Human Papilloma Virus (HPV) Infection within the mouth/ Eggans

Human Papilloma Virus (HPV) Infection within the mouth/ Eggans

Role of HPV.
Researchers have been trying for some time to find a definite association between throat cancer and HPV. There is a no doubt that carcinogens like cigarette smoking and tobacco increase the rates of throat cancer. Throat cancer can be deadly.The FDA has recently approved the HPV vaccine in males ages 9-26 years of age. This vaccine has already been approved for young females. Researchers claim that in men, this vaccine is only effective before the male has had sex and been exposed to HPV. Also, men are more susceptible to oral cancer than women and more likely to die from oral cancer than women. In addition, multiple partners or promiscuity is associated with oral cancer. However, although females may die from throat cancer, females are less likely to get oral cancer, while males who have sex with males are most vulnerable to oral cancer.

Oral Cancer
Each year, roughly 30,000 new cases are diagnosed and more than 8,000 people die from the disease. Studies suggest that 15% to 25% of oropharyngeal cancer cases are associated with HPV16, a particular type of HPV. Oral cancer forms in the oral cavity, which includes the lip, tongue, and hard palate; and the oral pharynx, which includes the soft palate, base of the tongue, and tonsils. Thus far, the HPV-related cancers are found in the tonsil area. Survival of oral cancer has not improved in 30 years. Decades may pass between HPV infection and oral cancer development.

In one scenario, a man can have one young wife dead from throat cancer; remarry and can have a second young wife dead from throat cancer. Both dying young. Would you say this man is the cause of both his wives dying from throat cancer? Did this man have something which caused the death of both his wives by the very same disease – throat cancer, while he showed no obvious external symptoms, and lived a long healthy life? It does say one thing: throat cancer can kill women. It kills swiftly. However, since this man or his wives did not provide any diseased human material to be tested, there is no way to know definitively what common factor existed in this family’s destruction from throat cancer. Knowing this (real case) scenario, would you allow someone you care for to have sex with this man? Would you ever lick the same icecream cone this one licked?

What should you do if you have knowledge or suspect someone you care for is having oral sex
As you can imagine, there is a search for a vaccine that might cure throat cancer, but it is still several years away. You might suggest typical safe sex advise such as: that scientists advise wearing condoms can prevent this disease. Then, you might make them aware of articles such as this one on this topic in particular. Below, are a few more articles which this site feels cover the subject of oral sex, oral cancer and HPV with gravity and scientific facts.

Related Articles:
Throat cancer: What, Why, Who and Everything you should know, before oral sex

Scientific articles supporting this discussion
1. An excellent article in 2003, by Jeanne Erdmann in the Oxford Journal of Cancer Research, which discusses in more detail the knowledge of throat cancer and the search for a preventive vaccine. It credits Stina Syrjänen, Ph.D., D.D.S., of the Turku-HPV group in Finland in 1983 for the first observations and connections between cervical cancer and oral cancer. It is interesting that a dentist may be the first line of diagnosis in this potentially deadly disease. Article #1

physicians are reporting an increase in the disease in patients with little or no history of smoking or drinking. Some of these cancers contain the human papillomavirus (HPV), most especially HPV16, a sexually transmitted member of the papillomavirus family linked to about half of all cases of cervical cancer…

the oral cancer field lags behind that of cervical cancer. Scientists still do not fully understand the natural history of the disease and the transmission routes of HPV and oral cancer. For example, HPV16 is found in pre-cancerous lesions in the cervix, but rarely in oral dysplasia, a precursor to oral cancer

2. Mayo clinic’s James M. Steckelberg, M.D., answers a query about “…does HPV infection increase cancer risk in men?” in this article #2. The short answer is yes, but the specific risks are different the doctor explains further about the high risk HPVs and advocates Gardasil for prevention.

3. An article by Adina Nack PhD on June 4, 2013 on “MICHAEL DOUGLAS’ CANCER CONFESSION: THE RISK OF HPV AND ORAL SEX”. The focus is on educating men about their cancer risk from HPV, and on removing the STD stigma so that men may seek a STD diagnosis and cure. Article #3.

4. An article by Centers of Disease Control on what is HPV.It discusses the signs and symptoms of diseases caused by HPV and other STD facts Article #4.

when the virus persists, or does not go away, HPV can cause normal cells to become abnormal and, most of the time you cannot see or feel these cell changes.
Warts can appear within months after getting HPV.
Cancer often takes years—even decades—to develop after a person gets HPV.

Approximately 79 million Americans are currently infected with HPV. About 14 million people become newly infected each year. HPV is so common that nearly all sexually-active men and women will get at least one type of HPV at some point in their lives.

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