2012 NAIAD Report on Status of Vaccine Research and Development


THE JORDAN REPORT, periodically reviews the progress in vaccine development and is published by NAIAD (USA). In recent years, there has been a growing, negative opinion towards vaccination. However, when one looks back 30 years one finds that life expentancy of the human being has been extended far more in the last century than in the several preceding thousands of years of human existence.

In 1981, the program of Accelerated Development of Vaccines was established by National Institute of Allergy and Infectious Diseases (NIAID) to build on the success of the past triumphs against important infectious diseases as diphtheria, measles, pertussis, poliomyelitis, tetanus, yellow fever, and others. In 1961, it was not unusual to see children crippled by polio. Today, that is rare. Clearly, vaccinations have contributed to a society which is healthier and preserves human life.  The new program was ably directed for 6 critical early years by William S. (Bill) Jordan (1917–2008). Hence, the periodical reviews are named after him. You may click here to read the 2012 review. It takes time to load, since it is large, and you may want to allow time for that.

Addressing Adverse Effect Concerns: Parents claim that their child showed the first signs of autism after a series of childhood vaccinations. While vaccine researchers do not find clinical support for this statement, they have removed mercury from their vaccines and also have preservative-free vaccines. The search for the causal factors for Autism Spectrum Disorder is ongoing.How is a decision maker to move forward facing such challenges?

Contents of the 2012 Jordan Report: 

Below is the Table of Contents covered in the 2012 Jordan Review. You may find a vaccine within your interests. To read more about each vaccine study, you will want to click here. Of particular interest to a worldwide audience might be Malaria, West Nile Virus, Chlamydia, Neglected tropical diseases like viral Dengue and a new emerging viral disease like Chikungunya.

Table of Contents
INTRODUCTION
Foreword by Anthony S. Fauci, M.D. ………………………………….. 3 Tribute by Carole A. Heilman, Ph.D. ………………………………….. 5
EXPERT ARTICLES
Vaccinomics and Personalized Vaccinology
Gregory A. Poland, M.D., Inna G. Ovsyannikova, Ph.D. and Robert M. Jacobson, M.D. …………………………………………………….11
Sex Differences in Immune Responses to Vaccines
Col. Renata J. M. Engler, M.D. and Mary M. Klote, M.D. ……. 19 Immunization and Pregnancy
Flor M. Munoz, M.D. ………………………………………………………… 27
Second-Generation Malaria Vaccines: A Definitive End
to Malaria-Related Deaths?
Vasee S. Moorthy, MRCP, Ph.D. ………………………………………….. 34
Structural Biology and Other Resolution-Enhancing Technologies in the Design of an Effective HIV–1 Vaccine Peter D. Kwong, Ph.D., John R. Mascola, M.D. and
Gary J. Nabel, M.D., Ph.D. ………………………………………………….. 40
New Methods for Analyzing Vaccine Responses
Mark M. Davis, Ph.D. and John D. Altman, Ph.D……………….. 46
Developing Vaccines for the Neglected Tropical Diseases
David J. Diemert, M.D., FRCP(C) and
Saman Moazami, B.A…………………………………………………………. 53
The Public Health Need for a Staphylococcus aureus Vaccine Scott K. Fridkin, M.D. and John A. Jernigan, M.D., M.S. …….. 66
Adjuvants—Past, Present, and Future
Nicholas I. Obiri, Ph.D. and
Nathalie Garçon, Pharm.D., Ph.D. ……………………………………….74
Progress, Promises, and Perceptions: The National Vaccine Plan—A Path Forward for the Coming Decade
Bruce G. Gellin, M.D., M.P.H. and Sarah R. Landry, M.A…… 85
VACCINE UPDATES
Dengue
M. Cristina Cassetti, Ph.D. …………………………………………………. 95
HIGHLIGHT BOX
Vaccine Against Chikungunya Virus in Development
Gary J. Nabel, M.D., Ph.D. and Ken Pekoc ……………………. 97
Severe Acute Respiratory Syndrome
Frederick J. Cassels, Ph.D. …………………………………………………… 98
HIGHLIGHT BOX
Vaccine Delivery Technologies
Martin H. Crumrine, Ph.D………………………………………….. 105 West Nile Virus
Patricia M. Repik, Ph.D…………………………………………………….. 106
HIGHLIGHT BOX
Henipaviruses (Nipah Virus and Hendra Virus)
M. Cristina Cassetti, Ph.D…………………………………………… 109
Group B Streptococcus
Xin-Xing Gu, M.D., Linda C. Lambert, Ph.D. and
Carol Baker, M.D………………………………………………………………..110
HIGHLIGHT BOX
CMV Vaccine Shows Promise
Walla Dempsey, Ph.D., M. Cristina Cassetti, Ph.D.
and Mason Booth………………………………………………………….114
HIV/AIDS
Rona L. Siskind, M.H.S……………………………………………………….115
HIGHLIGHT BOXES
Herpevac Trial for Women Concludes
Amanda Schleif, M.P.H……………………………………………….. 120
Chlamydia Vaccine Being Tested in
Nonhuman Primates
Harlan D. Caldwell, Ph.D. and Ken Pekoc …………………… 122
Promising HIV Vaccine Trial Results: RV144,
the Thai HIV Vaccine Trial
Rona L. Siskind, M.H.S. ………………………………………………. 126
1
Influenza
Linda C. Lambert, Ph.D. and Frederick J. Cassels, Ph.D. …… 127
HIGHLIGHT BOX
NIAID Centers of Excellence for Influenza Research
and Surveillance
Sarah E. Miers, J.D………………………………………………………. 132
Malaria
Peter D. Crompton, M.D., M.P.H. and Steven R. Rosenthal, M.D., M.P.H. …………………………………………………………………….. 133
HIGHLIGHT BOX
The International Centers of Excellence for Malaria Research
Malla R. Rao, Dr.P.H., M.Eng. …………………………………….. 134
Respiratory Syncytial Virus
Sonnie Kim, M.S. ………………………………………………………………. 139
HIGHLIGHT BOX
Impact of Regulatory Science on Influenza
Vaccine Development
David S. Cho, Ph.D., M.P.H…………………………………………. 139
Tuberculosis
Christine F. Sizemore, Ph.D. ……………………………………………… 144
HIGHLIGHT BOX
Hepatitis C Virus: Prospects for Vaccine Development
Sarah E. Miers, J.D. and Rajen Koshy, Ph.D. ……………….. 147 Rotavirus
Diana S. Berard ………………………………………………………………… 149 APPENDIXES
Appendix A: Status of Vaccine Research and
Development, 2012……………………………………………………………. 153
Appendix B: NIAID-Supported HIV Vaccine Candidates in Preclinical Development…………………………………………………… 179
Appendix C: Ongoing Clinical Trials of HIV Vaccine Candidates in HIV-Uninfected Adults……………………………… 180

Advertisements

Leave a comment

Filed under Health, Research, Science

Comments and Any Questions

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s