How do your genes control the lipid levels in your blood plasma?


How can two people lead the same unhealthy lifestyle and yet, one person remains healthy while the other develops fatty liver disease, and is waiting for a liver to become available for a transplant? The answer was discovered in a laboratory in Texas. Helen Hobbs MD is one of the leading bioscience visionaries with her novel lipid metabolism research to improve human health. She is Director at the McDermott center for Human Growth and Development which serves as the Center for Human Genetics at UT South Western.She has recieved Germany’s highly respected Heinrich Wieland prize for her research on lipids. This prestigious prize is given annually to an individual who has conducted outstanding research.

Her interests in fatty liver disease began when a pediatrician approached her. He had several Hispanic children who were quite obese and had developed fatty liver disease. Dr Helen Hobbs began to search for a genetic answer to explain this observation and you may click here to read the 2011 summary of her results published in the journal Science entitled, “Human fatty liver disease: old questions and new insights”. hobbs

Faced with the discovery that there is a gene that can predict which person may develop liver cirrhosis or liver cancer, what is the ethical way to handle the knowledge when a 3 year old in a family with this disease also has this gene. Which means this child will have to take extreme precautions. One of them is to prevent getting obese and remain super fit. How do you tell a 3 year old?

African Americans, interestingly, are the group least likely to develop fatty liver disease since this gene is less common than among Hispanics. Caucasians lie inbetween Hispanics and African Americans in their ability to develop fatty liver disease. You may click here to read the details in the 2008 scientific journal, Nature Genetics. For those of you interested in scientific jargon, the gene is PNPLA3. Chromosome number 22 is of specific interest. Some members of four generations of an obese family may carry this gene. Those who carry two copies of this type of gene will get a very sick fatty liver. Those who have only a single copy of this gene, will remain slightly healthier. This gene is inherited.

Fructose travels straight to the liver and is strongly associated with a rise in obesity. Corn syrup contributes fructose. Obesity is associated with fatty liver disease. Carbohydrates add to the problem.

Another ethical question: what is the role of society and community when they observe a person getting super obese? Does one tell them about the connection between this gene, obesity, role of fructose and carbohydrates leading to fatty liver disease?

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Could the cure for cancer be a simple master switch solution by a Massachusetts based company?


Yes, blocking of a few master genetic switches associated with “super enhancers” might be a simple cure for cancer, says Dr. Richard Young, of Whitehead research institute, MA, senior author in two papers in the prestigious, peer – reviewed paper, Cell, and founder of a start-up company, Syros Pharmaceuticals, with the goal to cure cancer. The company has raised 30 million dollars to support its goal to cure cancer by finding and switching off the master switches in each type of cancer. You may click here to read the Cell paper led by Dr. Jakob Loven, for “Selective inhibition of tumor oncogenes by disruption of super enhancers”, and here to read the Cell paper led by Dr. Warren A. Whyte, for “Master transcription factors and mediator establish super enhancers at key cell identity genes.  Both the papers have a single, master illustration explaining the main concept. It is must see to understand how simple the hypothesized solution is. images-1

Dr Young’s team says a normal cell regulation is remarkably less complex, with core genes controlled by only a few hundred super enhancers. With this hypothesis, cancer research focus is forever changed since April 2013, and gives remarkable insight to how a single fertilized egg from a father and mother can develop into a unique individual, with two-thirds of his/her diseases having a genetic determination. Loss of old super enhancers and assembling a cluster of new enhancers drives cell identity as a human grows develops.

For years cancer scientists have been reporting their discoveries of the mediators responsible for over expression of cancer genes. What makes Dr Young’s work more unique is that it suggests that a few master switches might control this gene at super enhancer regions. There are thousands of cancer gene transcription factors in the literature. One example is the study of pancreatic cancer, the fourth commenest cause of cancer related deaths in the western hemisphere. Several key genes have been shown to play a role in pancreatic cancer, including the oncogene K-RAS and several tumor suppresor genes including some from the TGFbeta signalling pathway. The researchers discovered that the Fibroblast growth factor receptor gene 4 (FGFR4) was overexpressed in almost two-thirds of pancreatic cancers. They found a research outside this gene called intron 1, was greatly extended in pancreatic cancer cells. Two sites binding transcripton factors and two sites binding mediators were identified, and additionally, the team discovered which mediator was essential for over expression of FGFR4 to cause pancreatic cancer. You may read about this pancreatic cancer work led by Dr. Helen C Hurst of London by clicking here. Might this deadly pancreatic cancer too be controlled by inhibiting one or more of the several hundred master switches?

Do you prefer a non scientific explanation of the above solution? A very simple explanation of the complex work done by Dr. Richard Young and his team of enthusiastic young scientists is given by Amy Maxmen in the respected weekly journal, Nature and you might read it by clicking here. She appropriately titles it “Super-powered switches may decide cell fate”. Different cells in the body have the same genes swithced on at different times. When such cells are switched on by a super enhancer complex due to unknown factors (as yet), then the cell becomes cancerous. You might say that cancer cells are “fueled” by “super enhancers”, and might suggest inhibiting such a fueling source to cure cancer and you might be correct to be hopeful, albeit with a heavy dose of patience. Last year it was discovered there are a million enhancers in the human genome. Dr Young speculates that some of these enhancers act together in large clusters and function as a unit. How are cancer cells able to employ such super enhancers to produce more of their harmful factors that lead to aggressive tumorsimages

Dr. Richard Young and his team of enthusiastic young scientists deserve to know if you support their goal. Do write to them if you do to encourage them. Scientists work long hours tied to a laboratory bench. Although they love their job to solve mighty goals, receiving your notes of encouragement will inspire them further. Do keep in mind that discovery through clinical trials with FDA approval to doctors office may take a decade or longer and might cost a billion dollars for each drug in research over that period. So 30 million dollars will not take them too far without your support and creative solutions to funding.
Email: Dr Richard A. Young and his team at young@wi.mit.edu
Snail mail: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA

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Creation of an artificial muscle that responds to artificial protein by UC Santa Barbara scientists


We have only begun to understand a biological motor. Cells are composed of biological filament system called the cytoskeleton, which very much resembles the bricks used to build a brick and mortar house. These tiny marvels are precise machines that run all the functions of a living being with a regular daily rythm, day after day, 24 hours a day. It runs on energy called ATP. That is very much like how electricity runs the house lights or a gallon of gas runs a car motor, in the same way, a living cell, be it a plant or animal requires energy in the form of ATP to run it’s “motor”. Scientists have often wished to harness this cellular energy. The health beneficial opportunities and fortunes to be made for the medical device manufacturers are only limited by imagination.

Discovery: Activating a Biological structure using a motor created with bacterial protein

On May 2012, a team of enthusiastic scientists at the University of California Santa Barbara have perfected a nano machine that runs on cellular ATP, well in a minute way. Olivier J. N. Bertranda, Deborah Kuchnir Fygensonb, and Omar A. Salehc, have demonstrated that they can trigger an artificial gel structure created with DNA building blocks that will respond to ATP and twitch. I hope I have access to a video soon to show it to you in action. For now, read more on:
1) Click “Scientists Build ‘Mechanically Active’ DNA Material That Responds With Movement When Stimulated“- if you want the Science Daily version;
2) Click “Active, motor-driven mechanics in a DNA gel” – if you want the Proceedings of the National Academy of Sciences dated Oct 8, 2012 version.

Did you find this research of value? Then do write to the team of scientists and congratulate them for their superb curiosity and ability to follow through and capture a vision of our future. Send them money too if it makes you happy. Your correspondence should be addressed as follows:
E-mail: saleh@engineering.ucsb.edu.

Here is a quote from their article:

Here, we describe the synthesis and characterization of an active gel using noncytoskeletal components. We use methods of base-pair-templated DNA self assembly to create a hybrid DNA gel containing stiff tubes and flexible linkers. We then activate the gel by adding the motor FtsK50C, a construct derived from the bacterial protein FtsK that, in vitro, has a strong and processive DNA contraction activity.

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2012 NAIAD Report on Status of Vaccine Research and Development


THE JORDAN REPORT, periodically reviews the progress in vaccine development and is published by NAIAD (USA). In recent years, there has been a growing, negative opinion towards vaccination. However, when one looks back 30 years one finds that life expentancy of the human being has been extended far more in the last century than in the several preceding thousands of years of human existence.

In 1981, the program of Accelerated Development of Vaccines was established by National Institute of Allergy and Infectious Diseases (NIAID) to build on the success of the past triumphs against important infectious diseases as diphtheria, measles, pertussis, poliomyelitis, tetanus, yellow fever, and others. In 1961, it was not unusual to see children crippled by polio. Today, that is rare. Clearly, vaccinations have contributed to a society which is healthier and preserves human life.  The new program was ably directed for 6 critical early years by William S. (Bill) Jordan (1917–2008). Hence, the periodical reviews are named after him. You may click here to read the 2012 review. It takes time to load, since it is large, and you may want to allow time for that.

Addressing Adverse Effect Concerns: Parents claim that their child showed the first signs of autism after a series of childhood vaccinations. While vaccine researchers do not find clinical support for this statement, they have removed mercury from their vaccines and also have preservative-free vaccines. The search for the causal factors for Autism Spectrum Disorder is ongoing.How is a decision maker to move forward facing such challenges?

Contents of the 2012 Jordan Report: 

Below is the Table of Contents covered in the 2012 Jordan Review. You may find a vaccine within your interests. To read more about each vaccine study, you will want to click here. Of particular interest to a worldwide audience might be Malaria, West Nile Virus, Chlamydia, Neglected tropical diseases like viral Dengue and a new emerging viral disease like Chikungunya.

Table of Contents
INTRODUCTION
Foreword by Anthony S. Fauci, M.D. ………………………………….. 3 Tribute by Carole A. Heilman, Ph.D. ………………………………….. 5
EXPERT ARTICLES
Vaccinomics and Personalized Vaccinology
Gregory A. Poland, M.D., Inna G. Ovsyannikova, Ph.D. and Robert M. Jacobson, M.D. …………………………………………………….11
Sex Differences in Immune Responses to Vaccines
Col. Renata J. M. Engler, M.D. and Mary M. Klote, M.D. ……. 19 Immunization and Pregnancy
Flor M. Munoz, M.D. ………………………………………………………… 27
Second-Generation Malaria Vaccines: A Definitive End
to Malaria-Related Deaths?
Vasee S. Moorthy, MRCP, Ph.D. ………………………………………….. 34
Structural Biology and Other Resolution-Enhancing Technologies in the Design of an Effective HIV–1 Vaccine Peter D. Kwong, Ph.D., John R. Mascola, M.D. and
Gary J. Nabel, M.D., Ph.D. ………………………………………………….. 40
New Methods for Analyzing Vaccine Responses
Mark M. Davis, Ph.D. and John D. Altman, Ph.D……………….. 46
Developing Vaccines for the Neglected Tropical Diseases
David J. Diemert, M.D., FRCP(C) and
Saman Moazami, B.A…………………………………………………………. 53
The Public Health Need for a Staphylococcus aureus Vaccine Scott K. Fridkin, M.D. and John A. Jernigan, M.D., M.S. …….. 66
Adjuvants—Past, Present, and Future
Nicholas I. Obiri, Ph.D. and
Nathalie Garçon, Pharm.D., Ph.D. ……………………………………….74
Progress, Promises, and Perceptions: The National Vaccine Plan—A Path Forward for the Coming Decade
Bruce G. Gellin, M.D., M.P.H. and Sarah R. Landry, M.A…… 85
VACCINE UPDATES
Dengue
M. Cristina Cassetti, Ph.D. …………………………………………………. 95
HIGHLIGHT BOX
Vaccine Against Chikungunya Virus in Development
Gary J. Nabel, M.D., Ph.D. and Ken Pekoc ……………………. 97
Severe Acute Respiratory Syndrome
Frederick J. Cassels, Ph.D. …………………………………………………… 98
HIGHLIGHT BOX
Vaccine Delivery Technologies
Martin H. Crumrine, Ph.D………………………………………….. 105 West Nile Virus
Patricia M. Repik, Ph.D…………………………………………………….. 106
HIGHLIGHT BOX
Henipaviruses (Nipah Virus and Hendra Virus)
M. Cristina Cassetti, Ph.D…………………………………………… 109
Group B Streptococcus
Xin-Xing Gu, M.D., Linda C. Lambert, Ph.D. and
Carol Baker, M.D………………………………………………………………..110
HIGHLIGHT BOX
CMV Vaccine Shows Promise
Walla Dempsey, Ph.D., M. Cristina Cassetti, Ph.D.
and Mason Booth………………………………………………………….114
HIV/AIDS
Rona L. Siskind, M.H.S……………………………………………………….115
HIGHLIGHT BOXES
Herpevac Trial for Women Concludes
Amanda Schleif, M.P.H……………………………………………….. 120
Chlamydia Vaccine Being Tested in
Nonhuman Primates
Harlan D. Caldwell, Ph.D. and Ken Pekoc …………………… 122
Promising HIV Vaccine Trial Results: RV144,
the Thai HIV Vaccine Trial
Rona L. Siskind, M.H.S. ………………………………………………. 126
1
Influenza
Linda C. Lambert, Ph.D. and Frederick J. Cassels, Ph.D. …… 127
HIGHLIGHT BOX
NIAID Centers of Excellence for Influenza Research
and Surveillance
Sarah E. Miers, J.D………………………………………………………. 132
Malaria
Peter D. Crompton, M.D., M.P.H. and Steven R. Rosenthal, M.D., M.P.H. …………………………………………………………………….. 133
HIGHLIGHT BOX
The International Centers of Excellence for Malaria Research
Malla R. Rao, Dr.P.H., M.Eng. …………………………………….. 134
Respiratory Syncytial Virus
Sonnie Kim, M.S. ………………………………………………………………. 139
HIGHLIGHT BOX
Impact of Regulatory Science on Influenza
Vaccine Development
David S. Cho, Ph.D., M.P.H…………………………………………. 139
Tuberculosis
Christine F. Sizemore, Ph.D. ……………………………………………… 144
HIGHLIGHT BOX
Hepatitis C Virus: Prospects for Vaccine Development
Sarah E. Miers, J.D. and Rajen Koshy, Ph.D. ……………….. 147 Rotavirus
Diana S. Berard ………………………………………………………………… 149 APPENDIXES
Appendix A: Status of Vaccine Research and
Development, 2012……………………………………………………………. 153
Appendix B: NIAID-Supported HIV Vaccine Candidates in Preclinical Development…………………………………………………… 179
Appendix C: Ongoing Clinical Trials of HIV Vaccine Candidates in HIV-Uninfected Adults……………………………… 180

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Two Traditional Plant-based Diabetic management from Africa, and India


Psidium and Perseaare two common plants used in effective health management for optimum results that often integrate traditional medicine with modern therapies.

Psidium guajava, is used in India from traditional times to manage diabetes (see 1).  This common red guava has been shown to have hypoglycemic (lowers blood sugar) and hypotensive (lowers blood pressure) activity (see 2) when a research study was conducted using leaf extracts in an African adults type 2 Diabetics group. Mechanism of this action is still speculative. Both stem bark and leaf extracts appear to have hypoglycemic (lower blood sugar) effects.

Persea americana, has been used in traditional medicine for its hypoglycemic (sugar lowering) effects (see 3). This plant, the common pear’s seed extracts were used to study diabetic induced rats (see 3).  It acts by a degenerative effects on the pancreatic islet cells. Thus, the author suggests that ethanolic extracts of the pear seeds may be used to reduce blood glucose levels and in diabetic management.

Do write to these researchers to encourage them on these research projects on type 2 diabetes:
Dr Ojewole Email: ojewolej@ukzn.ac.za ; Based currently in Department of Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa
Dr Edem Email: doedem@yahoo.com , Based at Department of Biochemistry,Faculty of Basic Medical Sciences University of UYO,P.M.B. 1017, UYO,Akwa Ibom State,Nigeria

Related Articles

1.  Stem barks of the common Red guava may have hypoglycemic effects.

2. Hypoglycemic and Hypotensive (lower blood pressure) effects of the leaf extracts of the common red guava.

3. Hypoglycemic effects of the seed extracts of the Pear seed.

4. War on Obesity and Diabetes by reducing the size of 16oz drinks in New York city

5. New York scientists engineer a unique way to switch on the insulin gene from a distance – with impact on diabetics managament

6. Could anti-CD20 cure Type 2 Diabetes?

7. Diabetes is an auto-immune disease
 

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The Red pea pod fungus that became a deadly meningitis causal agent


As the 15 fungal scientists at the Centers of Disease Control (CDC) work thirteen hours a day, seven days a week (see 1) on how to detect, understand and curtail this unusual meningitis, the larger community is wondering what could have prevented this meningitis. There are two fungi causing this recent deadly meningitis (see 2, 3, 4.). They are Aspergillus and Exserohilum. While Aspergillus has caused meningitis in the past, Exserohilum is the surprising enemy. While there are a few scientists already working on fungal meningitis (see 3, 5), there are none who had worked on Exserohilum for meningitis, but perhaps as a sinusitis causal agent or a plant pathogen. 

The current emphasis of the scientists working around the clock is to figure out how to detect the fungus that is causing the meningitis.  Since one of them has never caused meningitis before, there are no confirmed, FDA approved detection tests for the current crisis. This is one of the topmost and most urgent priorities of the CDC scientists. “The scale is much bigger than we have previously worked with”, says Dr. Ana Lituintseva, CDC Fungal Research Laboratory Team Leader (see 6). While most patients have been reported from among those who received spinal pain corticosteroid injections, there has been at least one report of meningitis from a patient who received a joint pain corticosteroid injection (see 2). Fortunately, this fungal infection is not contagious. Fungal medication is very toxic. It is not recommended to take the fungal medication as a precautionary measure, because fungi and humans are very similar. When you attempt to kill the fungus, you may harm the human. So, the advice is to listen to the doctor. In a following article we will explain how fungi are similar to humans.

The Red Pea Pod Fungus that causes an unusual meningitis

Why is one of the fungi causing this infection called “The Red pea pod”? Because it looks like a red pea pod. For a photo of what it looks like when it was observed causing an infection in plants click on 4; compare with this  photo (see 6) of what it looks like when it causes infection in humans as meningitis. Then, decide for yourself and begin to ask the question, how different are we humans from the common plants around us? The answer is important for the survival of our civilization as we know it today and begin to create an alternate civilization in space, Mars and the universe beyond us.

Related Articles
1. At CDC, scientists fight to halt a deadly fungus .
2.Fungal meningitis stats continue to rise.
3. What are the two fungi causing the meningitis outbreak in USA?
4. Exserohilum and Aspergillus: what turned them deadly?
5. Advances against Aspergillosus
6. CDC says one new death from meningitis

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What is the G-Protein receptor for which two scientists won the nobel prize?


What is the G-protein? They act as a gateway to how and what our bodies react. For example, Vitamin D exposure is critical to our health. How does our body know how much Vitamin D we have been exposed to? The answer is that there is a protein that recognizes Vitamin D when it is produced in response to sunlight. This protein is connected via another protein called G-protein. Through G-proteins, the human body controls virtually any important functions like fighting the common cold.  To learn more about how G-proteins control emerging diseases like autism and their description click here.  To see a gorgeous illustration of the G-protein click here. To know the names of the nobel winners click here.

You may want to know your G-proteins. A change in your G-protein may affect how much sunlight you need to be a healthy person. This may be quite different from that of your neighbor or best friend or spouse. Pharmaceutical companies owe half their drugs to the G-proteins. Antihistamines, beta blockers and anti-psychotic drugs to name just a few block buster drugs owe their success to the understanding scientists have of the G-proteins.

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Aspergillus and Exserohilum: what turned them deadly?


The recent outbreak of Meningitis (July – October 2012) has been deadly. Of the approximately 13000 individuals exposed to tainted steroid back pain injection (click here for details) 18 had died until October 8, 2012. Fortunately, the average healthy individual is able to fight off the causal agents of this outbreak – two fungi. Well, lets get to know these fungi better.  The two fungi are Aspergillus and Exserohilum.  Here, we cover Exserohilum.

Exserohilum
First described by Leonard and Suggs and subsequently reviewed by Sivanesan (see 11)

Exserohilum rostratum conidiophores
Fungal colonies are grey to blackish – brown
Source: Mycology, Adelaide University

Exserohilum sp. conidia
Note the strongly defined protruding truncate “exserted” hilum
Hilum is defined as the scar on the conidia at the point of attachment to conidiophore
Source: Mycology, Adelaide University

More commonly known as an invader of grasses (see 1;2), Exserohilum has rarely caused a disease in humans. While meningitis is known to have a fungal causal agent (see 5), it has never been by the genus Exserohilum (see 7,8). It is an emerging human pathogen and needs to be better understood (8). This genus while found to cause leaf spots and leaf stripes on certain plants (see 10), does not even invade healthy grasses, let alone healthy humans. Sivanesan described 20 species of Exserohilum in 1987 and is the established published source (see 11) on the illustrated biology, pathogenicity, toxin production and distribution of Exserohilum. Robert Leahy has added information on Exserohilum sp. leaf spots of Bromeliads (see 2). Bromeliads in their natural setting are fungus free. Since Bromeliads became increasingly desirable they are now cultivated under conditions where they are susceptible to destructive leaf streaks by this fungus. Hence, the study on how to recognize the symptoms and control them.

What turned the fungus deadly?

Very few scientists study human diseases caused by Exserohilum simply because they are so rare. They do cause  sinusitis (see 9). It has never been located in meningitis disease samples to date (see 8). Meningitis causing fungi are more commonly Aspergillus, Cryptoccocus and Candida (see 5), and Prof Robert Cramer’s laboratory is among the few who are studying the destructive process of human invasion by Aspergillus(see 5).

Certain types of Exserohilum are known to produce toxins, which could perhaps weaken or destroy/kill a weakened host like a plant or a human. A list of some of the toxins it produces are: Glyceolin, Cynodontin, Exserohilone, Monocerin, Monocerin, Ophiobolin A, and Ravenelin (see 10). The first two are produced by E. rostratum, the most commonly studied.

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What are the fungi that are causing the meningitis outbreak in USA?


Aspergillus fumigatus

75 clinics in 23 states in USA are monitoring their patients who received a spinal steroid injection for pain. They may be infected with a rare meningitis caused by a fungus. The name of the steroid is methylprednisolone acetate. The Calgary Herald’s Malcolm Ritter  discusses the fact that there were (on October 8, 2012), at least two fungi linked to this unusual meningitis outbreak and they are Aspergillus and Exserohilum. Therapy is limited by the fact that very few anti-fungals penetrate the blood-brain barrier and researchers are working on more effective antifungals (see scientists below).

The causal fungi were contaminating the vials of the steroid produced and packed only by the New England Compounding Center in Massachussetts. Dr.John Jernigan, an epideomologist at the CDC, is leading the charge against these fungi. He has been quoted by various news sources stressing the fact that unlike bacterial meningitis, this is a very rare type of meningitis with little clinical research (PBS – a video recording, NY Times, Wall Street Journal). According to Huffington Post’s Amanda Chen, patients in Tennessee, Indiana, Florida, North Carolina, Maryland and Virginia have developed Meningitis. Dr. William Schaffner, President of the National Foundation of Infectious Disease said that the causal fungus is commonly found all around us, normally does not make people sick, but does cause an illness in some immunocompromised people like those with AIDS, and is not contagious.

Meningitis may be caused by fungi, bacteria or virus. To get this disease from a tainted vial is highly unusual. Needless to say, this steroid has been recalled immediately. By October 7, 2012 there were 18 confirmed deaths from fungal meningitis linked to tainted steroid back pain spinal injections says the local Detroit CBS news. Only those patients who sought relief for back pain with a steroid spinal injection July to September 2012 should be concerned.  Senator Richard Blumenthal has called for extending the FDA’s monitoring authority, if necessary (Wall Street Journal)

FUNGAL MENINGITIS
The Centers For Disease Control and Prevention (CDC) USA, assures that fungal meningitis is not contagious. You may click here to reach the CDC site to learn about typical Fungal Meningitis. It talks about:
CAUSES
TRANSMISSION
RISK FACTORS -
SIGNS AND SYMPTOMS
RISK FACTORS
DIAGNOSIS
TREATMENT – usually IV medication and usually patients are immunocompromised already.

WHAT IS MENINGITIS?
The Tennessean has done such a wonderful job explaining this disease that you should probably click here to learn more about their explanations on:
What is meningitis and how many types are there?
What is Aspergillus Meningitis?
How is it diagnosed?
Should I go to the doctor for Aspergillus Meningitis?
Should I pursue other pain management options until this has been cleared?

THE DEDICATED SCIENTISTS WHO RESEARCH FUNGI THAT CAUSE MENINGITIS 
Do email these scientists and encourage them to continue their research. Send them dolloar bills if you must, but mostly tell them you appreciate their contribution.
ASPERGILLUS FUMIGATUS – involved in the tainted steroid outbreak

CRYPTOCOCCUS NEOFORMANS – not involved in this 2012 outbreak

EXSEROHILUM – involved in the tainted steroid outbreak (Old research click on 1 & 2; and 3 for Six newer citations)

Associate Professor William Steinbach
The source of the featured photo in this article

The Duke University’s mycology group studies several fungi that cause diseases of humans including Aspergillus. One of their researchers in the Division of Pediatric Infectious Diseases is Associate Professor William Steinbach. He is interested specifically in Aspergillus fumigatus because it is the leading killer of immunocompromised patients with cancer or following transplantation. You may write to him at: 427 Jones Bldg
Research Drive, Durham, N.C. 27710 or email him at bill.steinbach@duke.edu.

Texas A&M University has biologists who have recently discovered that ZOLOFT, a medication already FDA approved for and most commonly prescribed for depression, and can cross the blood-brain barrier, can pack quite the punch against Cryptococcus neoformans, a fungus that may cause meningitis. The two chief scientists who are working to discover anti-fungals against C. neoformans are Professor Mathew Sachs and Assistant Professor Xiaorong Lin and published in the July 2012 issue of the Journal of Antimicrobial agents and Chemotherapy, where they discuss how there are a limited number of anti-fungals today. Also, the fact that antifungals available today do not penetrate the blood-brain barrier thus complicating anti-fungal therapy. Their research so far is only in the lab but is promising. Sertraline or ZOLOFT acs by not allowing the fungi to synthesize proteins for their own use, thus destroying them. Address correspondence to Xiaorong Lin, xlin@bio.tamu.edu, or Matthew S. Sachs, msachs@bio.tamu.edu or you may write at Department of Biology, Texas A&M University, College Station, Texas, USA.

Professor Mathew Sachs

Assistant Professor Xiarong Lin

A meningitis causing fungus, Cryptococcus

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Do Anorexics and Autism Spectrum Disorder share any common characteristics?


Yes, say scientists in the journal, European Eating Disorder Review, published in 2011. Read the article by clicking here. They speculate if anorexia nervosa (AN) a version of autism spectrum disorders (ASD)?

Quote: ….

There are reports of disturbed processing of oxytocin (Odent, 2010) and dysdiadochokinesis (a neurological soft sign associated with developmental disorders) in both AN and ASD (Råstam, 1992; Råstam, Gillberg, & Wentz, 2003; Tchanturia, Morris, Anderluh, Collier, Nikolaou, & Treasure, 2004). Furthermore, AN and ASD appear to co-exist within families (Gillberg, 1985; Comings & Comings, 1991; Steffenburg, 1991) indicating that these observed similarities may reflect a direct genetic link.

….


Based on the proposed similarities between the cognitive profiles of the disorders, it was hypothesised that ASD and AN groups would not perform differently across tasks.

…Unquote

Read the article by clicking here.

What were the authors results?
Cognitive profiles of the groups were statistically similar, except for differences in the relative patterns of empathy scores. Interestingly, the scientists note that the triad of behavioural impairments (social impairment, communication impairments and restrictive and repetitive behaviours) are noted to cluster together and co-occur above chance expectations, even outside of a diagnosis of autism (Happé & Ronald, 2008; Wing & Gould, 1979). Yet, this clustering of all three cognitive features within a disorder appears fairly specific to Anorexics(AN) and Autism Spectrum Disorder (ASD).

The scientists add: There are, in fact, significant differences between the disorders. Whilst AN has more recently been described as a developmental disorder (Connan, Campbell, Katzman, Lightman, & Treasure, 2003), there are differences in age, gender and developmental stage of onset and there can be an association of low IQ and learning difficulties with ASD that is absent in AN.

Limitations The scientists list several limitations to this study.

Read more

What is Anorexia?

A severely Anorexic young woman


For those of you who do not know the current crisis of the eating disorder of young women and recently, young men, you might find this review very informative. I must warn you that some of the photos are quite disturbing. It includes a historical narrative of the changing image of the female body and shows the modern ‘anorexic’ women photos, some of whom have crossed the extreme and are dying. Now, it is happening to young men. I have no photos of young men here since it is a newer trend, probably. To see the photos and read the article on anorexia click here.

What is an Autism Spectrum Disorder (ASD)?
An autism spectrum disorder (ASD), also called a pervasive developmental disorder (PDD). The Massachussetts General Hospital says ASD is a biological brain disorder that significantly affects an individual’s ability to understand people, interpret events, communicate, and interact with others. These disorders are described as occurring on a spectrum because of the wide variability of impact they may have on everyday functioning. The scope, variety, and severity of symptoms differ in each individual, but in general, autism spectrum disorders are characterized by:

Difficulty with communication
Impairments in social skills and understanding of how to engage and interact with others
Unusual behaviors and interests (such as attachments to unusual objects or speaking in cartoon or movie scripts)
Read more.

 

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Why would twelve LeRoy New York school girls suddenly develop Tourette syndrome – like symptoms?


Jim Dupont and Beth Miller both have daughters who have presented with the tic like symptoms and both do not have a clue why this is happening reports Berkeley Brean of WHEC.com. Tourette is a neurological condition with an uncontrollable tic feature.

Early January 2012, the parents of LeRoy New York students were updated by Dr Gregory Young of the New York State Health Department, the state office of Mental Health and the LeRoy school authority. The parents were informed that although the symptoms presented were real, no cause could be pinpointed. Stress is one factor being blamed.

What factor or a group of factors could trigger a signal cascade to cause a cluster of Tourette like syndromes in one school district?

The parents of the twelve girls who came down around the same time in 2011 with Tourette like symptoms are quite concerned. These were twelve normal girls earlier. Not today. Jim Dupont, a parent interviewed is very upset and not optimistic about his 17 year old daughter’s future. His daughter was ready to drive and now cannot. Beth Miller found that her healthy daughter woke up one morning with twitches.

If you can help these families or help prevent future clusters please let us know by commenting here. We want to hear from you and know that you care. Please read Berkeley Brean’s article which has more from one of the young girls herself. You may also call Jim Dupont or Beth Miller at the numbers below and let them know that you care:
Dupont and Miller are starting a support group for all the parents. They think if they work together they can get somewhere.

Here is the contact information:

Jim Dupont: (585) 746-2001
Beth Miller: (585) 356-7508

We’ve posted the unedited interview with the commissioner from the health department here at http://www.whec.com. We encourage people to watch it. It may not answer all of your questions but it might answer a few.

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A young girl holding the pink breast cancer ribbon

Dr Miller and colleagues from cancer centers of North Carolina studied the genetic signatures of 674 breast cancer patients to predict how regulation of iron by an individual is linked to recovery. They published their work in the November issue of the journal Cancer Research in 2011.

Genes involved: There are 61 genes involved in regulation of iron and of them 49% appeared to be significantly associated with metastasis -free survival. This has a potential to affect therapeutic decision making.

Regulators of iron efflux: Dr. Nemeth and colleagues from California and Boston hospitals reported in an article in the journal Science in 2004 on how the liver regulates cellular iron levels. Hepcidin is a hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload whereas increased hepcidin leads to hypoferremia and the anaemia of inflammation. (cancer research 71:6728)

The hormone hepcidin binds to a protein ferroportin on the surface of cells. This signals the cells to internalize the protein ferroportin and degrade it. This leads to decreased export of cellular iron. This is a loop. Iron regulates the secretion of hepcidin from the liver, which regulates internalization of the protein ferroportin on cell surfaces, which controls iron export from cells. Less export leads to overload of iron in cells.

Iron overload disorders: It is important to have a balanced amount of iron in the cells. Too much or too little iron is bad. The amount of iron differs during different stages in one’s life with a menstruating woman needing far more iron than a post menopausal woman. An excellent 2011 review in the journal, Internal Journal of Hematology by Dr  Kaplan and colleagues at Utah school of Medicine summarizes the current knowledge on levels of iron in cells, disorders and anaemia.

Special Diet for iron overload: Read the Hemochromatosis cookbook and this excellent blog from the Iron Disorders Institute:: Iron overload. Find a doctor immediately who will listen to you and is knowledgeable about this topic. Usually a gastroenterologist or hematologist. Blood donation is often the suggested therapy for iron overload and appears to help.

Scientist to encourage in this field: If research in this field is important to you then do write to the researchers involved in such research and encourage them. The value of Dr Miller’s work can be emphasized by emailing her colleague Dr Torti E-mail: ftorti@wakehealth.edu

Dr Kaplan to encourage and for questions on iron overload Email:  jerry.kaplan@path.utah.edu

Scientists work alone, often long hours in isolated settings. Letting them know that you consider their work important inspires them and spurs them to undertake often risky research. Help them find funding. Shower them with accolades.

If you found this article useful, please let me know by either hitting the like button here or in the “About” section (if you enjoyed more than one article here). It would help me to know which topics you would want me to research and write here.

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January 5, 2012 · 4:20 pm

Tracking the seasonal flu, The History of the Flu Vaccine and The Flu Vaccine of 2011


The seasonal flu of 2011 arrived with the first confirmed case in Arkansas (Read more). The vaccination of the public swung into action with the seasonal flu vaccine components of 2011, which were exactly the same as the vaccine components of 2010, and described in my previous article, entitled, “Should I get the flu vaccine this year?”. The 2011 – 2012 flu season is going to be an ordinary one, unlike the one in 2009 and the far deadlier one in 2018, all of them caused by the same deadly swine flu H1N1 strain of the flu virus. First reported death from swine flu in 2009 was a 23 month old boy in Texas (Read more). The vaccination of the public swung into action in 2009. Why was 2018 the deadliest flu season in America with over 40 million estimated to be killed world-wide, far more than by the war?  Why was the 2009 flu season pandemic by the same flu virus strain  far less deadlier? The answer is the flu vaccine, the story of which I will tell you here.

A Flu Virus

The Story of The Flu Vaccine:
This year quite different from other years in the story of the Flu Vaccine and that is because Prof. Edwin Kilbourne passed away very quietly in 2011. He had devoted his entire life to the study of the flu virus and played a leadership role in the history of the development of the flu vaccine. I could tell you about Dr Kilbourne but to tell you why he is important, I would need to tell you about the 2018 flu pandemic.

Many have wondered why the Flu pandemic of 1918 is not mentioned as a turning point in American lifestyles in the History books. The fall of 2018 began just like another fall in the middle of a chaos of a country in the midst of the a world war. Stealthier than any human enemy, arrived a tiny microbe, the flu virus strain H1N1 on a crisp New England fall day in a Boston sea port. It must have arrived with some sailors. The September of 1918, the Boston Port was busy with war shipments of machinery. The war efforts allowed the virus to spread and diffuse. It was named the “Spanish Flu” or the “La Grippe”.

The flu pandemic of 1918 devastated many towns and military cantonments by acting very strangely. It wiped out America’s young and healthy, particularly those aged 20-35 years of age. There was no cure. The ill were advised to rest lying down, get fresh air, and to take plenty of fluids. The healthy were advised to avoid crowded, public places. Many wore masks to protect themselves or to prevent infecting others.

The Contagious First Wave of the 1918 Flu Pandemic
The best recorded first case was in Fort Riley, USA. On March 11, 1918, Private Albert Gitchell, a cook at Fort Riley, came down with a cold that required isolation. Within 5 weeks, 1,127 soldiers came down with the same symptoms and 46 of them died. Soldiers trained at Fort Riley before being deployed for the war effort in Europe and unintentionally spread the flu to Europe. When the flu began to ravage the people of Spain, the Spaniards publicly announced the disease. Spain was not in World War 1 and was not censoring its news and the world first heard of the deadly flu from Spain. Hence, the name, the “Spanish Flu”. By July 1918, the “Spanish Flu” had visited Russia, India, China and Africa and appeared to be dying out. Nobody guessed that this was only the first wave of the deadly flu pandemic about to be unleashed upon an unsuspecting world of humans by a microscopic, indestructible microbe.

The Contagious and Deadly Second Wave of the 1918 Flu Pandemic
Towards the end of August, a more deadly flu struck three world cities simultaneously. Boston, USA; Brest, France; and Freeport, Sierra Leone. The overwhelmed hospitals asked for volunteers to take care of their sick, who had to be housed in tents because of their sheer numbers.

Nurses care for the sick in tents

Some died within two days of first symptoms which included coughing violently, bleeding from their ears or turning blue in color and of course, extreme fatigue, fever and headache. The Spanish flu in its second wave struck suddenly and severely, killing some within several hours or a few days, while sparing others. Not surprisingly, panic ensued. Public events were canceled. Schools and theaters closed. Masks were required by many communities. Popular homemade remedies of the past did nothing to prevent or cure this disease. The dead piled up and mass graves had to deal with the bodies. There were not enough people to dig individual graves.

The Third Wave of the 1918 Pandemic
On November 11, 1918, an Armistice brought an end to World War 1. The hugging and kissing of the returning soldiers, some carrying the flu virus helped to create yet another epidemic wave, spreading a weaker version of the “Spanish Flu”. This wave was largely ignored because people had to concentrate on rebuilding their lives, while the pandemic lingered alongside and slowly petered away. Some say the flu lingered until next year but nothing as deadly as the early fall of 1918.

Preventing Another Deadly Pandemic
In an effort to prevent another deadly pandemic in the future, the USA government allocated 1 million dollars to learn more about the “Spanish Flu”. Among many recruited towards the laboratory war against the “Spanish Flu” was a young and eager Dr Edwin Kilbourne, a medical school graduate who was well-trained in virology laboratory research.

Dr Edwin D Kilbourne and Dr D E Rogers testing the Asian Flu virus

It was particularly hard for the Alaskan Indians for whom the death rate was elevated beyond that of the non-Indians. In one Inuit village in Alaska 72 of its 80 residents  died within 5 days in November 1918. Years later in 1997, a researcher dug up remains in the permafrost to isolate the flu virus and reconstructed the fatal strain H1N1. The Spanish Flu had traveled from Boston to Alaska in 2 months, killing many in it’s path.

In 1918 children would skip to the rhyme (Source: Crawford)
I had a little bird, Its name was Enza. I opened the window, And in-flu-enza.

The “Spanish Flu” of 1918 killed over 40 million people worldwide that flu season, while the World War 1 claimed about 16 million. Archives of photos here describe how the public and the government reacted to a situation of panic in the midst of a world war. These archives will help guide future leaders when faced with a similar crisis in the future. The Flu virus mutates over the years and has a habit of returning every few decades to cause epidemics or pandemics, that kill many. A cryptic, well-researched PBS movie (click here to watch) entitled, “1918 Spanish Influenza”, follows the story of the 1918 flu virus pandemic.

Native American death rate from the flu

on
swine flu death rates elevated for alaska natives and american indians

http://www.washingtonpost.com/wp-dyn/content/article/2009/12/10/AR2009121003937.html

The “Spanish flu” of 1918-19 devastated Inuit villages in Alaska. In one, Brevig Mission, 72 out of 80 residents died over five days in November 1918. A researcher extracted tissue samples in 1997 from a body buried there in a mass grave in the permafrost, allowing scientists to reconstruct that fatal strain of influenza.

CDC brochure advising that antibiotics will not work against the flu

http://www.cdc.gov/getsmart/campaign-materials/print-materials/Brochure-NativeAmerican.html

Arkansas has confirmed the first case of seasonal flu for 2011 in America   http://nwahomepage.com/fulltext-news/?nxd_id=276457

First reported death from swine flu in 2009 was a 23 month old boy in Texas    http://www.chron.com/news/health/article/Swine-flu-s-spread-pushes-Texas-to-cut-high-1744879.php

Tracking swine flu worldwide   http://www.nytimes.com/interactive/2009/04/27/us/20090427-flu-update-graphic.html

The United States Department of Health and Human Services  - a one stop to flu   http://1918.pandemicflu.gov/

The flu season that should be in history books    http://virus.stanford.edu/uda/   http://virus.stanford.edu/uda/

In 1918 children would skip to the rhyme (Crawford)  (source  http://virus.stanford.edu/uda/  )     I had a little bird,Its name was Enza.I opened the window,And in-flu-enza.     It first arrived in Boston in September of 1918 through the port busy with war shipments of machinery and supplies. The war also enabled the virus to spread and diffuse.  

Watch the PBS movie on the 1918 Spanish Influenza  http://www.pbs.org/wgbh/americanexperience/films/influenza/

Watch an archive of photos of the 1918 flu that killed an estimated excess of 40 million people worldwide while the world war 1 during the same time claimed an estimated 16 million lives  http://www.archives.gov/exhibits/influenza-epidemic/

For the federal government answers to frequent questions go to   http://www.flu.gov/general/

For a brief history of the Flu vaccine in The Times in 2008   http://www.time.com/time/nation/article/0,8599,1864920,00.html

The CBS documentary by Norman Gorin on the 1976 flu vaccine that caused 4000 people to claim damages, two thirds of them neurological   http://www.dailymotion.com/video/x9nnh6_swine-flu-1976-propaganda_news#rel-page-1

Natural questions followed on how to deal with the 2009 flu pandemic heeding the lessons of the 1976 mass flu vaccination  http://www.time.com/time/health/article/0,8599,1894129,00.html

Looking back it is not difficult to see why the 1976 flu vaccination decisions were taken.  http://www.haverford.edu/biology/edwards/disease/viral_essays/warnervirus.htm  but with the knowledge now, that the 1976 vaccine had the trigger that could make 8.3 per million people with most likely no prior illness sick from GBS versus 0.7 per million people with most likely a prior illness sick from GBS. Rationale for future vaccination programs.

Dr Edwin Kilbourne was the virologist who convinced the US Public Health Service to mass vaccinate. His was a stellar career, devoted to outwitting the Flu Virus. 1920 – 2011.  http://www.virology.ws/2011/02/25/edwin-d-kilbourne-md-1920-2011/    The New York Times only featured a miniscule portion of his career and his role in the 1976 flu vaccine fiasco and ignored his tremendous contribution to the modern flu vaccine.

Palese and Garcia-Sastra continue the search for a diagnostic, preventive and curative agent for all strains of Influenza. http://www.freepatentsonline.com/y2011/0027270.html  and http://en.wikipedia.org/wiki/Peter_Palese  and the team at Mt Sinai

Towards a broadly protective flu vaccine  http://www.jci.org/articles/view/37232  The team at St Judes Medical center  with the goal to define the role of cross reactive lymphocytes. Webster’s article on flu history with photo of little girls skip roping to the poem above  http://people.scs.carleton.ca/~soma/biosec/readings/influenza/influenza.html   Also has great related internet sources.

Egg free vaccine – my earlier article

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Why is Autism observed in America and not in underdeveloped countries?


Dr Andrew Wakefield wants to study the immigrant Somali families in Minnesota who have observed an unpleasant phenomenon: many of their children are Autistic, to an extent that this is being called ‘The American Disease”. Immigrants realize that this is not due to a lack of vigilance on the part of Somali doctors. They have the opportunity to visit their colleagues in their home country, and in comparing their own children and the children of their contemporaries, the result is glaring. A handful of countries, such as USA, UK, Australia, Vietnam and Sweden, have significantly higher numbers of autistic children, of which the Somali children are a small percentage.  Can we find a cure? How do we prevent more Autistic babies?

Autism amomg the immigrants from Somalia:
The controversial Dr Andrew Wakefield is of the opinion that the answer may lie within the Somali community in Minnesota. He is trying to recruit Somali families for his self-financed study. You can see a video here of Fox news interviewing Dr Wakefield on January 6, 2011. You can see a videohere of CNN channel interviewing Dr Wakefield on January 5, 2011 and a photo of a severely autistic boy.

A Healthy Boy in Famine Stricken Somalia

An Autistic Boy born in USA

UNICEF photo of families in Famine Stricken Somalia

The Somali Autistic children in Minnesota:
Anne Harrington, the special education district coordinator of Minneapolis district noted that the Somali families sometimes have more than one autistic child and it is a more severe form of autism. The kindergarten classes are about 12% Somali but autism cases in the early childhood special education classes are about 17% Somali. Read more and get involved.

It has been observed that there is a cluster of Somali families who have autistic children in Minneapolis. Other immigrant Somali communities have not experienced increased autism rates. A search for a set of triggers should be sought asking two questions:
First, why a cluster of Somali families in Minneapolis has autism, while the other Somali families do not and also, why these families have no autism in Somalia?
The next question is why are Autism rates higher among Somali families than in non Somali families in Minneapolis?

The Somali Autistic children in Sweden
It was observed that many Somali families in Sweden had children with autism. All these families had never heard of autism or observed any symptoms defined as autism in their homeland of Somalia. Dr Barnevick-Olssen and colleagues, psychiatrists in Sweden, published a report of their observations in 2008. They noted that children from Somali backgrounds are over-represented in the total group of children with autism and suggest a search for triggering factors is warranted. Read more. The Somalis living in Sweden have named it the “Swedish disease”.

Researchers in Sweden have requested access to a confidential database for information on Somali and Swedish children to search for clues. Some researchers ask if Somalis need more Vitamin D, coming from sunny Somalia to dark, long, Swedish winters. Is it the lack of sunlight and excessive use of sun protection? However, there is autism being observed in sunny Australia. Read more.

Video: “True wisdom about Autism” – An Autistic Child’s wish by Matthew ward who is Autistic and the forum that made it possible for him to present his wish, his mother, Nancy Alar. If there is one video you must see, it is this one, November 6, 2011. It made me cry. You will see for yourself in this video that an autistic child is intelligent. We must find a cure to help Autistic children speak again.

So what causes Autism?  What cures Autism?                                                                                                                               Scientists still cannot answer these questions. However, they fear that Dr Wakefield’s controversial published paper (see below) may have diverted the study of autism, with too much emphasis on an incorrect hypothesis. The search for both the set of triggers and therapy continues.

What is Autism?                                                                                                                                          When you see a severely Autistic child, you will ask, “What is wrong with this child?” I am not discussing the autism spectrum here, but only severe Autism. To truly understand the Autistic child see video number 4 below, as narrated by an Autistic child, whose simple wish is that he could speak better and that the world was educated to be tolerant of Autistic kids.

Why should all of us be more aware of Autism? Because Autistic kids are here to stay unless we find a prevention or a cure. The CDC says that 1 in 100 kids born today in America will be autistic. They will grow to become adults with Autism who will need to be employed. One in every hundred adults seeking employment in 2030 will be Autistic. You may be the employer or the colleague who will have to adjust because the Autistic adult may be effective at the job skill. What should be society’s role? Knowledge, tolerance and acceptance. Tomorrow it could be someone in your family.

Autistic children are easy to identify even by a layman. They are simply children who are very uniquely different from other children, with a defined set of one or more of the following characteristics:

* Does not communicate or talk – even though they talked as toddlers;
* Smashing head against a wall repeatedly;
* Increasingly violent and aggressive;
* Special bowel, food, intestine issues and acute hearing, olfactory and sense of touch;
* The child may throw unusual tantrums, and needs to be calmed down and not punished; Special aids workers with special training on Autism are superbly able to calm down an Autistic child. They may appear far more anxious than the average child, in a new situation.

Autism – The New Disease: The uninformed and those who are ignorant are naturally unaware of Autism. It is, after all, a “new” disease, a “life style” effect of our modern society’s advanced choices. For those of you who have never witnessed or been in contact with an autistic child, I have selected a few videos here of how Autism in our children exists in our daily life in developed countries. As responsible community members, we have a role in ensuring the safety of all our children. The Autistic child is very healthy, but possesses a special neurologically and intestinally dictated condition. We have not discovered what this phenomenon or set of triggers that produce an autistic child is so far. We owe our Autistic children a decent, safe place in our community.

Videos of Autistic children and how our community responds:
1) An 11 year old Autistic child being beaten by untrained aids in a school bus;
2) A father of an Autistic child in Canada, shoots his 11 year old son and then himself, after learning his child would have to be housed in a facility that does not understand the special needs of an Autistic child;
3) Hopes of Autistic children graduating from a special school;
4) “True wisdom about Autism” – An Autistic Child’s wish by Matthew ward who is Autistic and the forum that made it possible for him to present his wish, his mother, Nancy Alar. If there is one video you must see, it is this one, November 6, 2011. It made me cry.

Who is Dr Andrew Wakefield?                                                                                                                 Dr Wakefield published a paper in The Lancet, saying that the MMR vaccine is linked to the rise of rates of autism in children. Subsequently, his medical license of revoked with concerns raised that his publication was an ‘opinion piece’ and not a scientific paper. Panicked parents avoided and some still continue to avoid the MMR vaccine which prevents measles, mumps and rubella. This avoidance of vaccine has raised concern among the health care community. His co-authors discovered much later that Dr Wakefield had been financed by a law firm, with an intention to sue vaccine manufacturers with the results of his study data. This is a serious conflict of interest which had not been disclosed prior to publication. The fraud allegations arose because of the twelve children in his study, five of the children were autistic before receiving the MMR vaccine and three of the children were not autistic. Dr Wakefield defends himself from the fraud allegations by saying that the claims of the link between the MMR vaccine and autism came from the parents.  Such parents remain Dr Wakefields core group of supporters and continue to believe autism is caused by the MMR vaccine. Dr Wakefield prefers to use the term “linked” rather than “cause” when discussing MMR vaccine and Autism today.

Impact on Health Care Resources:
 However, we are running out of time. Our burden to our future health care community is mind boggling. We have a large population of aging baby boomers presenting with Alzheimers. This is already draining the medical in house facility resources. What will happen when the Autistic children out live their parents? They are very healthy. Originating from different cultural, ethnic and immigrant backgrounds and yet, most presenting with the future task of requiring safe supervision. Civilized society has to begin preparation to face this unique care giver situation of looking after a healthy, aging population, unable to navigate the world on their own.

Lets begin to ask: How are we going to take care of Autistic adults as their baby boomer parents age with Alzheimers, Parkinsons, Multiple Sclerosis or simple frailty? These children will grow up to be adults who will need supervised living. Autism research funding: who is paying and how much?. The time to begin the dialogue in today. George Braddock, President of Creative Housing Solutions LLC is offering solutions for community living for adults with autism.

Related Article
Italian court rules MMR causes Autism: parents sued court for forcing parents to vaccinate child with MMR and win

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Multiple Sclerosis cured by hook worms?


In 2007, researchers Dr Correale and Dr Farez, in Argentina discovered that their Multiple Sclerosis patients with a hook worm infection appeared to fare better than those without a worm infection.

Variety of Hookworms

The Intestinal Hookworm

Early clinical trials in MS patients are showing reduction in size of brain lesions. This may not be a cure, but even a low rate of lesion reduction is a promising therapy. What is more important is that this is a natural therapy which shows why people in developing countries may be developing Multiple Sclerosis. There are some clinical trialsunderway, which are trying to see how best to deliver a ‘doze’ of worms or their eggs to get the best results. Brain lesions are being tracked before, during and after a treatment with worms. The initial patterns shown on MRIs is encouraging and studies are in progress.

How does the hook worm act on MS patients? Researchers believe that in MS the immune system has an excessive response to it’s own brain tissue; the presence of the worm’s anti-inflammatory system lessons this response. In doing so, the brain lesions lessen. In other words, the worms suppress the patient’s overactive immune system. The worms need to do this to settle inside the human gut. It is possible that as humans evolved along with nature, our gut system and our immune system evolved to adjust to a constant presence of other gut worms and germs. The developed world’s decision to clean our gut of worms and germs may have been too harsh. Definitely, in MS the presence of worms in the gut makes it far more pleasant for the brain.

Follow your gut: Earlier, it was believed that MS was a caucasian disease when Asian countries reported no MS. Then, in the recent decades, Asians settling in developing countries were developing MS, leading researchers to conclude that MS is a disease of a developed country lifestyle. This, is further proof that the Argentina researchers discovered how the underdeveloped life style may be protective for our human brain.

Respect the hookworm. ‘Follow your gut’ has new meaning.

How to thank the scientists? Dr Correale and Dr Ferez’s original article showing the immune connection between hookworms and MS in 2007 has been cited 91 times. Now, if you want to encourage science of this caliber and in this field, shower these two scientists with your letters and emails. Let them know how much you appreciate them. Read their original article published in 2007. You may encourage them further by emailing them

E-mail: jcorreale@fleni.org.ar

The same scientists have published a 2011 paper showing that patients infected with worms showed significantly less relapses and include updated information. You may want to read their original article published in 2011.

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Should I get the flu vaccine this year?


Although, the 2011-2012 combination in the flu vaccine, is the same as the 2010-2011, an effective way you can protect yourself against a flu virus infection is through vaccination.

The Flu Virus

However, current vaccination approaches rely on achieving a good match between circulating flu virus strains and the isolates included in the vaccine formulation.  The recommendation is made by the World Health Organization  collaborating centers. Such a match is often difficult due to a combination of factors, one being that the recommendations are made six months prior to the initiation of the flu season, and the flu viruses are constantly undergoing change.

What if the formulation of the vaccine this year is the same as the previous year? The US Centers for Disease Control (CDC) advice that for optimal protection it is safest to get vaccinated against the flu every year. The CDC recommends all people above six months get vaccinated annually; especially the young and the elderly and gives information specific to the 2011-2012 season, including the vaccine formulation, which is exactly the same as the 2010-2011 combination, but is different from the 2009-2010 and earlier combinations. Some non-vaccinated people got quite ill and weak for a very long time in the fall of 2009 from what could have been the H1N1 flu. The vaccinated people apparently were protected or only had mild flu-like symptoms and lost little productive time.

Get vaccinated annually: A Boston.com article by a Globe staff, Deborah Kotz, gives a simple explanation why one needs to get immunized annually in spite of the same combination of strains in the vaccine. If you are naturally infected by the flu virus, your body can retain that immune memory for a life-time. On the other hand, when you are vaccinated by the same flu virus, your body’s immune memory becomes weaker over time, and we do not know currently whether you will have an appropriate immune response if infected next year.

According the CDC, certain people should get advice on whether they should get vaccinated; especially those with egg allergy or latex allergy.

If you have an egg allergy:

A Scientist Cultivating the Flu vaccine in Live Eggs - A labor intensive effort

When you have to make a decision about getting a flu vaccine, which is the vaccine currently grown only in egg in most countries, then you should seriously consider medical supervision because you may have options. They are rather limited in the USA versus Europe and I have detailed current strategies in a previous article on flu vaccination and egg allergy.  The options in Europe are quite different from those currently available in the USA. You may also read “Next generation of flu vaccines coming of age: Cell – based technology may replace egg – based flu vaccines“, by Teddi Dineley Johnson.

What is the combination in the 2011-2012 flu Vaccine? There is an international effort to create that single, life-time flu vaccine, but until then the vaccine combination will need to be reassessed every year. The 2011-2012 combination in the flu vaccine, which is the same as the 2010-2011,  is:

A/Cal/7/2009 (H1N1) – like

A/Perth/16/2009 (H3N2) – like

B/Brisbane/60/2008 – like antigens

If you have a latex allergy: There is both the traditional injection version and a new, intradermal version vaccine available this year.  If you have a latex allergy you may want to take advice and choose a latex free version. The package insert says that the dermal version prefilled syringe tip caps (Fluzone) may contain natural rubber latex to which you may have an allergic reaction if you are allergic to latex. The intradermal version is specially designed to not hurt at all, unlike a needle in the arm version, which many find painful. Either way, your choice of vaccination this year will have the same combination of flu virus.

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Yoga can reduce blood pressure but know your body’s injury potential


A clinical study led by holistic researchers in Florida Atlantic University,Boca Raton,studied the effects of yoga on hypertensive patients in Thailand. You may click here to read the 2005 article published in the journal, Holistic Nurse Practice in 2005. The researchers, Ruth McCaffrey, Pratum Ruknui, Urai Hatthakit, Payao Kasetsomboon, studied a group of hypertensive patients in Thailand, both male and female, to determine the effectiveness of a yoga program on hypertensiion and stress. They concluded that the experimental group showed significantly decreased mean stress scores and blood pressure, heart rate, and body mass index levels compared with the control group.

High blood pressure is when your blood pressure is usually higher than it should be. It is also called hypertension.. If your blood pressure is not lowered, there is risk for damage to your eyes, brain, heart, blood vessels, and kidneys. Talk to your doctor. Ask if you are at risk for having high blood pressure.

This study is easy to test on yourself.
Borrow or buy a blood pressure monitor. They are very small and portable. Make two charts. On one write no yoga. On the other write with yoga. On both write headings for the following columns:
1) Activity
2) Food or drink
3) Stressful event
4) Exciting or sad event
5) Date
6) Time
7) Blood pressure Diastolic
8) Blood pressure Systolic
9) Pulse

Now, simply measue your own blood pressure every two hours. Note, if you exercised or walked the dog or cooked or shopped. Especially important to note if you met friends, colleagues or aquaintances
Note under food if you had a meal or a coffee (which has caffeine) or tea (herbal or regular) or water or salty or sugary snacks or fruit/ vegetable snack
Note all the other self explanatory columns

Next day, follow a supervised hypertension yoga program. Measure your own blood pressure at the same times as on the day with no yoga. Try to follow the same routine and eat the same meals and drink the same drinks. For people with diabetes or kidney disease, blood pressure lower than 130/80 is good. Lower than 120/80 is ideal. For the average individual blood pressure lower than or equal to 120/80 is ideal.

Compare the results of your own two charts; one with yoga and one after just a single supervised hypertension yoga program. Make your own conclusions for your own body.

Keep in mind that no two people are alike.
You are a unique individual. Read how to avoid sports related injuries by clicking here. Yoga was never meant to be a sport. It is a reverant, spiritual, slow breathing, stretching, restfull, practically no impact routine. Poorly trained, irresponsible, irreverant individuals who call themselves yoga teachers with little knowledge of yoga and the purpose it serves, are hurting yoga enthusiasts. Avoid them. Find the right yoga teacher. What works for you may not necessarily work for your neighbor or best friend or a relative. Your genes are your own unique signature and dictate how you respond to stress and being around people you like or dislike. If you enjoy shopping for groceries while your friend finds vacuuming relaxing which stresses you out, then the two activity charts will record different results for such people.

Invest in research on effectiveness of yoga on your own hypertension
Yoga may easily serve one level of stress. However, to conclude if yoga will reduce the levels of daily stress in your personal routine, invest in the research on the effectiveness of yoga on your own hypertension. You deserve it. Go on. Take the step. Also, you might need two yoga routines a day instead of doing it all at one time. Discuss with your yoga supervisor. If your research shows that you are hypertensive at 2 pm daily, then enquire if is there a short routine that you could personally follow that might ease your stress levels. It might do you wonders by keeping an extra yoga mat in your office. Simply lay it down and do a routine for 5 minutes. Measure your blood pressure with or without yoga at same time in the office over two days at the time when the stressful event occurs daily. Perhaps, your boss walks in at the same time everyday to chat with you. If that stresses you out daily at the same time, measure your blood pressure one day right after the boss leaves. Next day, lay down the yoga mat and do a short yoga routine discussed with your yoga supervisor. Measure your blood pressure. Did the yoga help you?

Can yoga cause injuries?
There have been several recent reports on yoga related injuries. Listen to your body. Go to three different teachers before choosing one. The following articles cover yoga related injuries very well. Read them well before trusting any yoga teacher. The first one is the most important.
1) Top 10 Sports – Related injuries and yoga poses to avoid them
A must read
2)How yoga can wreck your body by NY Times
3)Practising safe yoga – 5 tips to avoid injuries by Huffington Post

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The proportion of flu and pneumonia related deaths is now slightly above epidemic threshold

For the first time in USA, the Influenza (Flu) season of 2012 – 2013, has become an eipidemic. Which means, there is a good chance either you or somebody you know is sick from the flu. This flu season is unlike the previous year’s mild flu season and totally took the people by surprise.

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January 16, 2013 · 11:03 pm

Cranberry Juice does not prevent recurrent Urinary Tract Infection in a clinical trial


Professor Betsy Foxman, Director, Center of Molecular and Clinical Epidemiology of infectious diseases at University of Michigan School of Public Health led a double-blind, placebo controlled trial on the effectiveness of Cranberry Juice in preventing urinary tract infectious. The research concluded that drinking 8 oz of 27% of Cranberry juic daily did not prevent a recurrence of UTI.  To read this article published in the 2011 you may click here.

This article definitely shows that people have to be careful in avoiding the sources of recurrent UTI. This study was done on college girls.  UTI patients might prevent a recurrence by avoiding unhygenic conditions that perhaps present the UTI causal agent.

Dr. Betsy Foxman

Dr. Betsy Foxman

Cranberry juice has health benefits touted through centuries. This study does show that it does not replace the need to follow hygenic practices in prevention. Modern science has been unable to explain the total health benefits of a natural food. Perhaps, a simultaneous question one could have added during the study is whether the general health of the college girl drinking Cranberry juice was better than the girls on placebo, given all other life style factors being equal. Perhaps, Cranberry prevents further downstream complications arising from a UTI. We look forward to the research on Cranberries. It benefits all to have a better scientific understanding of the natural world around us.

Cranberries are highly sought after. They are packed with nutrients and antioxidants. The benefits of a natural source of nutrients and antioxidants cannot be underestimated. They have developed an ability to grow under extremely challenging conditions in bogs. Natural Cranberry farmers take great efforts in maintain their Cranberry bogs in pristine condition. To read Russel Avery’s wonderful article on “How Cranberry Bogs Work” click here. It is a fascinating presentation on the farmer’s efforts to keep Cranberry crops strong. It makes one respect the juice we ingest so quickly.

Cranberries must be very hardy to thrive in a place as filthy as a bog. Darren McCollester/Getty Images from "HowStuffWorks" by Russel Avery

Cranberries must be very hardy to thrive in a place as filthy as a bog.
Darren McCollester/Getty Images from “HowStuffWorks” by Russel Avery

Cranberries ready to be made into Cranberry Juice

Cranberries ready to be made into Cranberry Juice

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Natural food anti-fungals

Eating your way to anti-fungal health through Thyme, seaweed, and more may help against the yeast (Candida sp.). There is no research to show that it does or does not have an effect against other fungi. However, good food is never boring!

Quote 

  • Good scientific evidence:
  • Zinc: Zinc formulations have been used since ancient Egyptian times to enhance wound healing. Evidence from human trials suggests that zinc pyrithione shampoo may be an effective treatment for tinea versicolor fungal infections of the scalp. Side effects were not noted. Additional research is needed before a strong recommendation can be made.
  • Zinc is generally considered safe when taken at the recommended dosages. Avoid zinc chloride since studies have not been done on its safety or effectiveness. While zinc appears safe during pregnancy in amounts lower than the established upper intake level, caution should be used since studies cannot rule out the possibility of harm to the fetus.
  • Unclear or conflicting scientific evidence:
  • Bishop’s weed: Limited available human study used 8-methoxypsoralen (8-MOP), a photoreactive plant compound from bishopsweed, for the treatment of tinea versicolor. Clinical studies are needed before a conclusion can be made.
  • Use cautiously in patients with photosensitivity as bishop’s weed may be photoreactive, and cause phototoxic skin damage, phototoxic dermatitis, and pigmentary retinopathy. Use cautiously in patients with bleeding disorders or taking anticoagulants, NSAIDs/anti-platelet agents, or herbs or supplements that increase risk of bleeding because bishop’s weed may have additive effects and increase the risk of bleeding. Use cautiously in patients taking drugs or herbs or supplements metabolized by cytochrome P450 as bishop’s weed may increase the effects of these agents. Use cautiously in patients with eye disorders, as bishop’s weed may cause ocular toxicity. Avoid in patients with known allergy/hypersensitivity to bishop’s weed, its constituents, or members of the Apiaceae family.
  • Bitter orange: Limited available human study found promising results using the oil of bitter orange for treatment of fungal infections. However, due to methodological weakness of this research, further evidence is needed to confirm these results.
  • Avoid if allergic or hypersensitive to bitter orange or any members of the Rutaceae family. Avoid with heart disease, narrow-angel glaucoma, intestinal colic, or long QT interval syndrome. Avoid if taking anti-adrenergic agents, beta-blockers, QT-interval prolonging drugs, monoamine oxidase inhibitors (MAOIs), stimulants, or honey. Use cautiously with headache, hyperthyroidism (overactive thyroid), or if fair-skinned. Avoid if pregnant or breastfeeding.
  • Cinnamon: There is currently a lack of available evidence to support the use of cinnamon for AIDS patients with advanced oral candidiasis. More study is needed in this area.
  • Avoid if allergic or hypersensitive to cinnamon, its constituents, members of the Lauraceae family, or Balsam of Peru. Use cautiously if prone to atopic reactions or if taking cytochrome P450 metabolized agents, anticoagulants (blood thinners), insulin or blood sugar-altering medications, antibiotics, or cardiovascular agents. Avoid if pregnant or breastfeeding.
  • Cranberry: Limited laboratory research has examined the antifungal activity of cranberry. Reliable human studies supporting the use of cranberry for fungal infections are currently lacking. Further research is warranted in this area.
  • Avoid if allergic to cranberries, blueberries, or other plants of the Vaccinium species. Sweetened cranberry juice may affect blood sugar levels. Use cautiously with a history of kidney stones. Pregnant and breastfeeding women should avoid cranberry in higher amounts than what is typically found in foods.
  • Garlic: Garlic is used both medicinally and as a food spice. Several studies describe the use of garlic as a topical antifungal to treat fungal infections of the skin, including yeast infections. More research is needed in this area.
  • Use cautiously as garlic can cause severe burns and rash when applied to the skin of sensitive individuals. Avoid if allergic or hypersensitive to garlic or other members of the Lilaceae(lily) family (e.g. hyacinth, tulip, onion, leek, or chive). Avoid with a history of bleeding problems, asthma, diabetes, low blood pressure, or thyroid disorders. Stop using supplemental garlic two weeks before and immediately after dental/surgical/diagnostic procedures with bleeding risks. Avoid in supplemental doses if pregnant or breastfeeding.
  • Pomegranate: In clinical study, an extract of pomegranate was shown to be as effective as a commonly used oral gel when used topically to treat candidiasis associated with denture stomatitis (mouth sores). Additional study is needed to confirm pomegranate’s antifungal effects.
  • Avoid if allergic or hypersensitive to pomegranate. Avoid with diarrhea or high or low blood pressure. Avoid taking pomegranate fruit husk with oil or fats to treat parasites. Pomegranate root/stem bark should only be used under the supervision of a qualified healthcare professional. Use cautiously with liver damage or liver disease. Pomegranate supplementation may be unsafe during pregnancy when taken by mouth. The bark, root, and fruit rind may cause menstruation or uterine contractions. Avoid if breastfeeding due to a lack of scientific data.
  • Probiotics: Early research suggests that cheese containing probiotics may help reduce the risk of a fungal mouth infection, called thrush, in the elderly. More research is needed in this area.
  • Probiotics are generally considered to be safe and well-tolerated. Avoid if allergic or hypersensitive to probiotics. Use cautiously if lactose intolerant. Caution is advised when using probiotics in neonates born prematurely or with immune deficiency.
  • Propolis: Propolis is a natural resin created by bees to make their hives. Propolis is made from the buds of conifer and poplar trees and combined with beeswax and other bee secretions. In human study, a commercial propolis ethanol extract from Brazil, formulated to ensure physical and chemical stability, was found to inhibit fungal infections of the mouth, such as oral candidiasis. Additional research is needed to confirm these findings.
  • Avoid if allergic or hypersensitive to propolis, black poplar (Populas nigra), poplar bud, bee stings, bee products, honey, or Balsam of Peru. Severe allergic reactions have been reported. There has been one report of kidney failure with the ingestion of propolis that improved upon discontinuing therapy and deteriorated with re-exposure. Avoid if pregnant or breastfeeding because of the high alcohol content in some products.
  • Seaweed, kelp, bladderwrack: Bladderwrack (Fucus vesiculosus) is a brown seaweed found along the northern coasts of the Atlantic and Pacific oceans and North and Baltic seas. Another seaweed that grows alongside bladderwrack is Ascophyllum nodosum, andit is often combined with bladderwrack in kelp preparations. Laboratory research suggests that bladderwrack may have antifungal activity. However, reliable human studies to support this use are currently lacking in the available literature.
  • Avoid if allergic or hypersensitive to Fucus vesiculosus or iodine. Avoid with a history of thyroid disease, bleeding, acne, kidney disease, blood clots, nerve disorders, high blood pressure, stroke, or diabetes. Avoid if pregnant or breastfeeding.
  • Selenium: Selenium is a mineral found in soil, water, and some foods. Commercially available 1% selenium sulfide shampoo has been reported as equivalent to sporicidal therapy in the adjunctive treatment of the yeast infection tinea capitis. However, further high-quality evidence is warranted.
  • Selenium sulfide shampoo has also been studied as a possible treatment for tinea versicolor. However, research results are inconclusive.
  • Avoid if allergic or hypersensitive to products containing selenium. Avoid with a history of non-melanoma skin cancer. Selenium is generally regarded as safe for pregnant or breastfeeding women. However, animal research reports that large doses of selenium may lead to birth defects.
  • Tea tree oil: Although tea tree oil has been found to have activity against several fungus species in laboratory study, there is currently insufficient human evidence to determine if it is an effective topical treatment for onychomycosis, tinea pedis (athlete’s foot), or thrush (oral Candida albicans).
  • Tea tree oil may be toxic when taken by mouth and therefore, should not be swallowed. Avoid if allergic to tea tree oil or plants of the Myrtle (Myrtaceae) family, Balsam of Peru, or benzoin. Use cautiously with a history of eczema. Avoid if pregnant or breastfeeding.
  • Thyme: Thyme has been used medicinally for thousands of years. Beyond its common culinary application, it has been recommended for many indications based on proposed antimicrobial, antitussive, spasmolytic, and antioxidant activity. Thyme essential oil and thymol have been shown to have antifungal effects. Topical thymol has been used traditionally to treat paronychia (skin infection around a finger or toenail) and onycholysis (fungal nail infection)Currently, there is insufficient reliable human evidence to recommend for or against the use of thyme or thymol as a treatment for fungal infections.
  • Avoid if allergic or hypersensitive to thyme, members of the Lamiaceae (mint) family, any component of thyme, or rosemary (Rosmarinus officinalis). Avoid oral ingestion or non-diluted topical application of thyme oil due to potential toxicity. Avoid topical preparations in areas of skin breakdown or injury or in atopic patients due to multiple reports of contact dermatitis. Use cautiously with gastrointestinal irritation or peptic ulcer disease due to anecdotal reports of gastrointestinal irritation. Use cautiously with thyroid disorders due to observed anti-thyrotropic effects in animal research of the related speciesThymus serpyllum. Avoid if pregnant or breastfeeding.
 

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January 15, 2013 · 3:51 am

Should my baby get the flu vaccine?


The CDC says that infants younger than 6 months cannot get the flu vaccine. In this case, the role of the caregiver is important and hence, they must remain healthy and may wish to follow the CDC recommendations on precautions and advie for caregivers of children younger than 2 years old below. An excerpt:
Children Younger Than 6 Months at Higher Risk

Children younger than 6 months are at higher risk of serious flu complications, but are too young to get a flu vaccine. Because children younger than 6 months cannot get a vaccine, but are at high risk for serious flu-related complications, safeguarding them from influenza is especially important. This fact sheet provides advice to help caregivers (for example, parents, teachers, babysitters, nannies) protect children younger than 6 months from the flu.

Unquote.

For information on Egg free vaccines you may wish to click here.

CDC advice for caregivers of children below 2 years of age:
1. Take time to get the flu vaccine
2. Take everyday preventive steps – washing your hands often, covering mouth, keep baby 6 feet away from sick people, keep hands (and germs) away from face
3. Talk to doctor about antiviral drugs: which are most effective in first two days of illness

The CDC advises ensuring the infants cold or flu does not progress into pneumonia. Actively seek out advice on how to prevent flu from progressing into pneumonia.

Here is a study by pediatricians that shows that most babies begin to get sick with flu after they are 6 months old.  The mother’s ability to fight the flu virus is transmitted to the child while pregnant and does offer the new born to six month child a healthier start to life. However, a third of the new borns under six months did get the flu in this study. The Centers of Disease Control of USA (CDC) recommends that all infants above 6 months be vaccinated annually against the flu. You may click here to read the CDC recommendation on December 2012.

You may want to discuss with your pediatrician if your child is more than six months old. Maternal immunity transferred to the infant may postpone the need to immunize the infant. However, since two – thirds of the infants over 6 months in this 1997 study did get the flu, the discussion with the pediatrician becomes important. Also, the infant is getting a number of other immunizations and the expert discussion will allow you to avoid an unnecessary vaccine.

If the flu season is particularly harsh like in early 2013, then it might be advisable to not delay the discussion on immunizing your child over 6 months of age. The CDC does not recommend getting a child under 6 months getting the flu vaccine.

To read the scientific research article entitled “Influenza virus infections in infants” published in the Pediatric Infection Disease Journal click you may want to click here. It was published in 1997 but the results still apply.

The authors of this study are:
GLEZEN, W. PAUL MD; TABER, LARRY H. MD; FRANK, ARTHUR L. MD*; GRUBER, WILLIAM C. MD†; PIEDRA, PEDRO A. MD

Prevent the fluids from collecting in the ear and causing a ear infection.

Related Article
History of the flu vaccine
Egg free vaccine

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Did you know that your medicine might damage your nerves?


You take medicine to cure an illness. Did you know that your medicine might have a side reaction? Most people may not get serious side reactions and can tolerate their medicine and begin to feel better. Very few, however, may get a side reaction called peripheral neuropathy or numbness of fingers from nerve damage. In most cases, stopping the medicine will stop this damage.

If you want to read more about what to do if your fingers feel numb after taking a certain few prescribed drugs, then click on the title of the following excellent current scientific articles, which are not too unpleasant to read because they are so full of simple facts. However, always consult your doctor since the risks must be balanced with the positive aspects of taking this medicine.

Peripheral neuropathy

Many more agents are suspected of causing neuropathy than discussed. Despite the lengthy and fastidious drug approval process, rare and idiosyncratic causes of medication-induced neuropathy may only become evident after wide-usage. Medication-induced toxicity should be at least considered in new cases of neuropathy including apparent idiopathic forms. Also importantly, patients with existing neuropathy of known or presumed cause should have their current regimen and planned therapy considered for potential neurotoxicity. Some preventative agents against chemotherapy toxicity show promise, but none are yet approved for routine use against neurotoxic effects.

Platinum neurotoxicity

Current research has shown insight into the mechanisms of nerve damage caused by the platinum agents. After entering the DRG, the platinum agent forms an adduct with DNA. Apoptosis has been observed in DRG neurons following cisplatin treatment both in vitro and in vivo (31) and is correlated with increased platinum-DNA binding in these DRG neurons (31). Oxaliplatin and cisplatin differ in their severity of neurotoxicity to the DRG. Cisplatin produced about three times more platinum-DNA adducts in the DRG (32) than equimolar doses of oxaliplatin, consistent with clinical observations that cisplatin is associated with greater neurotoxicity.

A genome wide association study (which asks if your genes dictate a tendency towards nerve damage)

Purpose:Sensory peripheral neuropathy is a common and sometimes debilitating toxicity associated with paclitaxel therapy. This study aims to identify genetic risk factors for development of this toxicity. Experimental Design: A prospective pharmacogenetic analysis of primary breast cancer patients randomized to the paclitaxel arm of CALGB 40101 was used to identify genetic predictors of the onset and severity of sensory peripheral neuropathy.

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Can you have an unwanted reaction from a drug?


Yes, because genetically you are unique. Even though the medicine worked perfectly well on every person you know, your body may be different and might react to either the drug or the components in which the drug is made, referred to as the inactive ingredients.

So, if you feel something is not quite right after taking a medicine, check the name of:
1) The active ingredient
2) The list of inactive ingredients. Usually innocuous for most people, some ingredients are not well-tolerated by all.

The saying that “you can make some people happy all of the time and all of the people only some of the time” definitely applies to wonder drugs. There will always be a few people who will be unhappy and some who will be somewhat happy, while the majority will be pleased.

How is that? Your genes. You are a unique individual, and quite different from your immediate circle of friends, but slightly similar to many members of your family and most similar to a few members of your immediate family. Know your genes and you will be a happier person. We are not quite there yet, but I attended a presentation by one of the Nobel Prize winning discoverers of the DNA helical structure of our genes. He predicts a future when we will have little chips in our body, informing all who must know, our entire genetic code. Your medication will be personalized to your own genes.

If you have not liked biology before, be prepared to love it. In the future, your doctor will be talking about “your genes require that I give you this particular dose of this medicine and I must avoid giving you these additives because you personally react to these ingredients”. In other words, you will be familiar with your genes to get personalized medical attention. Many companies are already working for this glorious future.

Until then, what are we to do? Well, we need to be open to the fact that not all medicines will be tolerated by our body. Just because your neighbor Tom loves this medicine, or your coach Yuri recommends it highly, or your chef Xin Lee has enjoyed it for years does not mean that you will not get diarhea or nausea or heart burn or an allergic reaction. For example, Tamiflu has recently become controversial. It has caused deaths in some individuals while presumably helping others with serious flu – like symptoms. The manufacturer of Tamiflu claims it prevents the severe flu from progressing to pneumonia. Others claim it does not work as promised and might even cause death. You may click here to read more about Maria Cheng’s wonderful article in Yahoo news, Nov 12, 2012) discussing the effects of a drug being stock-piled for a deadly flu pandemic.

For a more scientific explanation and differentiation of terms you may want to click here. It defines adverse effect, adverse reaction, drugs, medicine and more. It is rather formal science reading but a pleasure if you want to understand why you should not feel shy to speak up when you feel a medicine “just does not feel right”. The article was published in the respected medical journal Lancet in 2000, when personalized medicine studies began to emerge in earnest. The authors are scientists from Uppsala Monitoring Centre, WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden and and Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK. An excerpt from the article is below.

You may direct questions or interest to
Dr Jeffrey K Aronson (e-mail: jeffrey.aronson@clinpharm.ox.ac.uk)

If you wish to encourage such work do write or email these scientists and encourage their work. Let them know you appreciate personalized medicine research. If not, all medicines will continue to be made in “one size fits all” mode. Would you buy a dress, blouse, pant made for a person ten times your size? You must have replied “NO”! Then, soon you will wish personalized medicine was already here. Your personal chip is on its way.

Quote:

We therefore propose the following definition of an adverse drug reaction: “An appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product.”…..

……The terms “adverse reaction” and “adverse effect” are interchangeable, except that an adverse effect is seen from the point of view of the drug, whereas an adverse reaction is seen from the point of view of the patient. However, the terms “adverse effect” and “adverse reaction” must be distinguished from “adverse event”.

Unquote
Read more.

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Coenzyme-Q: Consider it but use caution – it may lower blood pressure


Are there any safety concerns? I would certainly say, yes!
1) If you always had low blood pressure and now have high blood pressure, monitor your blood pressure regularly. Coenzyme-Q might lower your blood pressure, perhaps below your previous normal. So, monitoring is highly advisable. You might want to read the paragraph under “Safety concerns” by clicking here for the Medline Plus list of safety concerns. Medline Plus is an advice site for the public by the National Institutes of Health, USA.
2) While it helps with preclampsia during certain pregnancies, this Medline site also strongly cautions against taking drugs without supervision during pregnancy. Several drugs considered quite safe have resulted in deformed babies. So, this cautionary advice is not to be taken lightly.

Is Coenzyme-Q beneficial? I would say, yes!
Most people prescribed statins can benefit from its regular use. It may have increased the lifespan of this generation by a healthier decade perhaps. However, a percentage of people have an adverse reaction to statins. Not all, simply a percentage. This may be particularly severe for a cohort and prompted the Pharmaceutical giant, Bayer, to recall its statin. This cohort may have had a genetic factor that predisposed them to a severe reaction to statins. Others had a favorable response. For those who have had a serioius adverse reaction to statins and need a statin alternative, Coenzyme-Q might be the answer, but again, under a physician’s supervision. You may click here to read where to access the full article by Texas medical scientists on “Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation”.You may email their chief scientist to encourage further research but also with questions you might have regarding replacing statins with Coenzyme-Q.
Email: Dr. Langsjoen langsjoen@compuserve.com
Briefly, his teams observations are summarized below:
-50 patients were evaluated for adverse statin effects (myalgia, fatigue, dyspnea, memory loss, and peripheral neuropathy)
-Began supplemental CoQ(10) at an average of 240 mg/day
- follow-up demonstrated a decrease in fatigue from 84% to 16%, myalgia from 64% to 6%, dyspnea from 58% to 12%, memory loss from 8% to 4% and peripheral neuropathy from 10% to 2%.

Want to learn more about Coenzyme-Q? The best site that I found for the public was the one by the New York University’s Langone Medical Center, which you might access by clicking here. I love the way it tells you the history of Coenzyme-Q and how it works and who benefits most from using it. For example, I enjoyed learning that the Japanese discovered it and use it regularly and are it’s primary manufacturers.

Who should take statins? I would strongly recommend reading this wonderfully detailed, well-balanced February 2012 article by Alice Parks in the Times magazine’s Health and family section by clicking here. It covers the FDA warnings and recent updates. It also clarifies hysteria versus rationale in “FDA Warns Statin Users of Memory Loss and Diabetes Risks”. Read more.

Does eating red beets help? Coenzyme-Q is manufactured by fermenting red beets. That makes a good case for introducing red beet regularly in your diet. Who knows how the body processes red beets internally and maybe eating more red beets may assist those who want to avoid medication.

Now, I have given you a wonderful set of well-researched articles to read and decide for yourself whether you should eat red beets, and add Coenzyme-Q to your vitamin shelf.

If you had a unique experience with Coenzyme-Q, do alert our readers, who are a special brand of people who are unafraid of a healthy dose of science in any explanation.

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